Epidermal growth factor (EGF) A61G polymorphism and EGF gene expression in normal colon tissue from patients with colorectal cancer

Figures & data

Table I.  Patient characteristics.

Age Median/range	72/47–91
Gender Male/female	41/40
Topography No (%)
Colon	57 (71)
Rectum	19 (22)
Other	5 (6)
Classification No (%)
Dukes A	8 (9)
Dukes B	30 (37)
Dukes C	39 (48)
Other	4 (5)
EGFA61G genotype No (%)
A/A	27 (33)
A/G	39 (48)
G/G	15 (19)

n = 81.

Figure 1.  Distribution of age and EGF gene expression levels in normal colon tissue according to EGF A61G genotype. The left side boxplots (orange) represent the EGF gene expression levels in normal colon and the right side box plots (blue) the age in years.

Table II.  Median gene expression levels according to EGF A61G genotype (*p < 0.05).

Genotype	EGF gene expression (qEGF/qBA) in CRC tissue. Median (Range)	EGF gene expression (qEGF/qBA) in normal colon tissue. Median (Range)
A/A	0.12 (0.04–2.0)	0.49 (0.01–2.28)*
A/G	0.18 (0.01–6.4)	0.85 (0.35–4.75)*
G/G	0.119 (0.03–2.5)	1.52 (0.39–5.55)*

Figure 2.  Scatter plot of EGF gene expression in CRC versus normal colon tissue.

Figure 3.  EGF gene expression levels in colon tumour and normal colon tissue.