Changes in alcohol intake and risk of upper digestive tract cancer

Figures & data

Table I.  Characteristics of all subjects at the first examination by changing alcohol intake, Copenhagen City Heart Study, Denmark, 1976–78.

Changes in alcohol intake drinks/week	Females (number)	Males (number)	Age (mean)	Smoking (% smokers)	Income (% < 4 000 DKK)	BMI (mean kg/m^2)	Educational level (% <8 years)
≤ − 7	140	266	48.5	60.8	19.4	24.9	53.2
−6.9–1	1 600	1 146	51.2	59.0	23.2	25.2	61.0
−0.9–0.9	2 178	729	54.0	55.5	33.8	25.2	70.9
1–6.9	1 188	1 023	52.0	62.2	19.1	24.8	57.8
7–14	371	609	52.0	69.1	18.7	25.0	56.0
>14	193	912	50.6	77.2	15.8	25.7	60.1

Table II.  Alcohol intake at second examination and risk of upper digestive tract cancer, Copenhagen City Heart Study, Denmark, 1981–2002.

Alcohol intake (drinks/week)^a	HR (95%CI)^b
<1	1.00^c
1–6	0.6 (0.3–1.3)
7–14	1.1 (0.6–2.1)
15–21	1.0 (0.4–2.1)
22–41	1.2 (0.5–3.1)
42–68	2.5 (1.3–5.0)
69 +	3.3 (1.2–9.6)
Common test^d	p = 0.002
Trend-test^e	p < 0.0001

^aAdjusted for age (underlying time-scale), sex, smoking, educational level, average income and body mass index.

^bHR, hazard ratio; 95%CI, 95% confidence interval.

^cReference category.

^dχ²-statistics with 6 degrees of freedom.

^eχ²-statistics with 1 degrees of freedom.

Table III.  Changing alcohol intake and the hazard ratio of upper digestive tract cancer, Copenhagen City Heart Study, Denmark, 1981–2002.

Changes in alcohol intake (drinks/week)^a	(cases/person years at risk)	HR (95% CI)^b
≤7	(2 / 6 617)	0.5 (0.1–2.5)
−6.9–1	(22 / 43 514)	1.2 (0.5–2.7)
−0.9–0.9	(14 / 44 491)	1.0^c
1–6.9	(20 / 34 595)	1.3 (0.6–2.7)
7–14	(12 / 14 735)	1.4 (0.6–3.3)
>14	(35 / 16 142)	2.5 (1.1–5.3)
Common test^d		p = 0.024
Trend-test^e		p < 0.0001

^aAdjusted for age (underlying time-scale), initial alcohol intake, sex and changes in smoking.

^bHR, hazard ratio; 95%CI, 95% confidence interval.

^cReference category.

^dχ²-statistics with 5 degrees of freedom.

^eχ²-statistics with 1 degrees of freedom.