Survival in ovarian cancer patients by histology and family history

Figures & data

Table I.  Hazard ratios for ovarian cancer patients diagnosed between 1993–1999 according to histologies.

				Cause-specific suurvival					Overall survival
Histological types	Cases	Median year of diagnosis	Median survival time (months)	Deaths	Percent	HR	95%	CI	Deaths	Percent	HR	95%	CI
Epithelial ovarian cancer, reference*	4494	1996	39	2580	57.4	1.00			3067	68.2	1.00
Papillary serous cystadenocarcinoma	1407	1996	34	940	66.8	1.00			1062	75.5	1.00
Undifferentiated carcinoma	154	1996	31	98	63.6	0.96	0.78	1.18	114	74.0	0.96	0.79	1.17
Clear cell carcinoma	207	1996	66	91	44.0	0.59	0.47	0.73	104	50.2	0.58	0.48	0.71
Endometrioid carcinoma	607	1996	65	268	44.2	0.55	0.48	0.63	329	54.2	0.58	0.51	0.66
Serous cystadenocarcinoma	469	1996	40	286	61.0	0.88	0.77	1.01	318	67.8	0.86	0.76	0.97
Mucinous cystadenocarcinoma	473	1996	70	171	36.2	0.49	0.41	0.57	232	49.0	0.56	0.48	0.64
Others	1177	1996		726	61.7	1.04	0.94	1.15	908	77.1	1.14	1.04	1.24
Sex cord-stromal tumors	286	1996	77	80	28.0	0.42	0.34	0.53	121	42.3	0.53	0.44	0.63
Granulosa cell carcinoma	145	1996	94	13	9.0	0.11	0.07	0.19	30	20.7	0.21	0.15	0.30
Mullerian tumor	55	1997	12	36	65.5	1.57	1.13	2.18	47	85.5	1.70	1.27	2.26
Others	86	1995		31	36.0	0.59	0.41	0.84	44	51.2	0.70	0.52	0.94
Germ cell tumors	101	1996	84	21	20.8	0.42	0.27	0.65	24	23.8	0.41	0.27	0.61
Teratoma	41	1996	90	5	12.2	0.22	0.09	0.53	6	14.6	0.22	0.10	0.49
Others	60	1996		16	26.7	0.52	0.32	0.85	18	30.0	0.49	0.30	0.77
Borderline epithelial tumors	1168	1996	92	23	2.0	0.02	0.02	0.04	159	13.6	0.14	0.12	0.16
Serous cystadenoma	348	1995	91	2	0.6	0.01	0.00	0.03	43	12.4	0.12	0.09	0.16
Papillary serous cystadenoma	269	1997	92	4	1.5	0.02	0.01	0.05	36	13.4	0.13	0.10	0.19
Mucinous cystadenoma	541	1996	93	17	3.1	0.04	0.02	0.06	77	14.2	0.13	0.11	0.17
Others	10	1996		0	0.0				3	30.0	0.32	0.08	1.28

HR, hazard ratios, adjusted for age, period, region and socioeconomic status. Percent, percent of deaths. Bold type, 95%CI does not include 1.00.

*, for subtypes of epithelial ovarian cancer, using papillary serous cystadenocarcinoma as reference.

Table II.  Hazard ratios for cause-specific and overall survival in daughters diagnosed with ovarian cancer in the 1990s whose mothers were diagnosed before 1990.

				Cause-specific survival					Overall survival
Parameters	Cases	Median year of diagnosis	Median surviva1 time (months)	Deaths	Percent	HR	95%	CI	Deaths	Percent	HR	95%	CI
Sporadic cases, reference	3025	1995	67	1392	46.0	1.00			1598	52.8	1.00
Mothers with ovarian cancer before 1990	80	1995	51	50	62.5	1.49	1.12	1.98	53	66.3	1.38	1.05	1.81
Mothers' survival time (month)
< 12, reference	27	1994	33	20	74.1	1.00			22	81.5	1.00
12-59	27	1995	51	17	63.0	0.93	0.43	2.03	18	66.7	0.84	0.39	1.79
> = 60	26	1995	67	13	50.0	0.78	0.32	1.89	13	50.0	0.65	0.27	1.56
P value for trend test							0.08					0.04

HR, hazard ratios, adjusted for age, period, region and socioeconomic status. Percent, percent of deaths.

Bold type, 95%CI does not include 1.00.

Table III.  Hazard ratios for cause-specific and overall survival in mothers diagnosed with ovarian cancer before 1990 whose daughters were diagnosed in the 1990s.

				Cause-specifie survival					Overall surviva1
Parameters	Cases	Median year of diagnosis	Median survival time (months)	Deaths	Percent	HR	95%	CI	Deaths	Percent	HR	95%	CI
Sporadic cases, reference	13741	1978	30	8290	60.3	1.00			11171	81.3	1.00
Daughters with ovarian cancers in the 1990s	80	1977	18	60	75.0	1.37	1.06	1.76	75	93.8	1.34	1.07	1.68
Daughters' survival time (month)
< 60, reference	45	1976	14	38	84.4	1.00			42	93.3	1.00
> = 60	35	1977	30	22	62.9	0.54	0.28	1.01	33	94.3	0.62	0.35	1.12

HR, hazard ratios, adjusted for age, period, region and socioeconomic status. Percent, percent of deaths.

Bold type, 95%CI does not include 1.00.