Validation of the graded prognostic assessment index for patients with brain metastases

Figures & data

Figure 1.  Kaplan-Meier curves for overall survival for the Graded Prognostic Assessment (GPA) index.

Table I.  Pretreatment characteristics of the 232 patients included in this study

Parameter	Number (%)
Extracranial metastases present	131 (56)
Uncontrolled primary tumor	92 (40)*
Median Karnofsky performance status	70% (range 30–100)
Median age	57 years (32–81)
Median number of brain metastases	2 (1-approximately 50)
Median volume of the largest brain metastasis	11.6 ml (0.1–238)

*missing data in 29 patients (13%)

Table II.  Comparison of the survival results with four different prognostic indices in all 232 patients

	RPA I	RPA II	RPA III	BSBM 3	BSBM 2	BSBM 1	BSBM 0	GPA 3.5–4	GPA 3	GPA 1.5–2.5	GPA 0–1	SIR 8–10	SIR 4–7	SIR 1–3
Number of patients (%)	22 (11)	123 (59)	63 (30)	20 (10)	61 (30)	88 (44)	34 (17)	17 (7)	36 (16)	108 (47)	71 (31)	16 (7)	145 (65)	61 (27)
Median survival in months	10.8	3.2	2.0	11.5	3.9	2.4	1.9	10.3	5.6	3.5	1.9	8.7	4.1	1.7
% 6-months survival	64	30	18	70	37	22	18	65	50	38	10	69	41	10
% 1-year survival	41	16	10	45	22	11	3	41	31	21	1	44	22	2

RPA: recursive partitioning analysis class; BSBM: basic score for brain metastases; GPA: graded prognostic assessment; SIR: score index for radiosurgery