Squamous cell carcinoma of the hypopharynx: Single-institution outcome analysis of a large cohort of patients treated with primary non-surgical approaches

Figures & data

Figure 1.  3-year loco-regional control (a) and disease-free survival (b) for the entire cohort of 501 patients

Table I.  Univariate analysis correlating prognostic factors with outcome

Prognostic factor	No of patients	3-yr LRC (%)	p-value	3-yr DFS (%)	p-value
Primary Site
PFS	372	48.3	0.303	41.3	0.383
PC	48	39.7		35.2
PPW	69	76.8		46.8
NOS	12	48.6		48.6
T Stage
T1-2	187	49.7	0.056	49.4	0.014
T3-4	314	43.1		36.9
N Stage
N0	218	57.3	0.045 (N0 vs N1)	54.3	0.016 (N0 vs N1)
N1	115	40.5	0.006 (N1 vs N2/3)	35.3	0.009 (N1 vs N2/3)
N2-3	168	33.0	<0.001 (N0 vs N2-3)	27.0	<0.001 (N0 vs N2-3)
Overall Stage
I	8	100	0.022 (I vs IV)	100	0.011 (I vs IV)
II	77	58.0	<0.001 (II vs IV)	54.7	<0.001 (III vs IV)
III	225	47.8		43.8
IV	191	34.7	<0.001 (III vs IV)	28.8	<0.001 (III vs IV)
Age
= 55 yrs	222	37.3	<0.001	35.6	0.003
> 55 yrs	279	54.9		45.1
Sex
Male	487	44.7	0.949	41.7	0.992
Female	87	49.0		45.0
Modality
XRT alone	364	46.3	0.263 (XRT vs NACT)	41.1	0.446 (XRT vs NACT)
NACT-RT	37	29.9	0.517 (NACT vs CT-RT)	29.9	0.546 (NACT vs CT-RT)
Conc CT-RT	100	49.1	0.144 (NACT vs CT-RT)	45.5	0.314 (NACT vs CT-RT)
*XRT dose
= 70 Gy	253	50.9	0.525	47.7	0.187
66 < 70 Gy	67	50.1		40.1
*Overall XRT time
< 52 days	181	53.2	0.260	47.7	0.399
= 53 days	139	47.8		44.6

Abbreviations: LRC = loco-regional control; DFS = disease-free survival; PFS = pyriform sinus; PPW = posterior pharyngeal wall; PC = post cricoid; NOS= not otherwise specified; XRT = external radiotherapy; NACT-RT = neoadjuvant chemotherapy followed by radiotherapy; conc CT-RT= concurrent chemoradiotherapy

*Analysis restricted to 320 patients (receiving at least 66 Gy)

Figure 2.  3-year loco-regional control (a) & disease-free survival (b) as a function of overall stage grouping

Figure 3.  Younger age as a poorer prognostic factor for loco-regional control (a) as well as disease-free survival (b)

Table II.  Multivariate analysis of prognostic factors

Prognostic factor	Loco-regional control			Disease-free survival
	HR	95% CI	p-value	HR	95% CI	p-value
Age (=55 vs >55 years)	0.64	0.49–0.83	0.001	0.70	0.55–0.90	0.005
T stage (T1-2 vs T3-4)	1.23	0.88–1.71	0.219	1.35	0.98–1.86	0.065
N-stage (N0 vs N + )	1.82	1.30–2.55	0.001	1.97	1.42–2.72	<0.001
Stage (I-II vs III-IV)	0.97	0.59–1.69	0.90	0.88	0.52–1.50	0.65

Abbreviations: HR = hazard ratio; 95%CI = 95% confidence interval