Survival for ethmoid sinus adenocarcinoma in European populations

Figures & data

Table I.  Number of cases of ethmoid sinus adenocarcinoma in adults during 1983–1994 in 11 European countries. Proportions of population coverage (%coverage), microscopically verified (MV), male (male), unspecified cancer sub-site by country. Numbers of morphologic groups and incidence rates by country.

Country/Registry	No of cases	%coverage	%MV	%male	% unspecified site codes (ICD9 1609)	Unspecified morphology, number	Squamous cell carcinoma, number	Other specified morphlogy, number	Incidence of all cancers of nasal cavities /100 000/year*	Incidence of all ethmoid cancers /100 000/year*	**Ratio
UK, group 1
ENGLAND *	96	62.5	92	85	2	63	88	32	0.91	0.089	10.17
SCOTLAND	11	100	100	45	3	3	9	4	0.76	0.062	12.24
WALES	5	100	100	60	3	11	7	3	1.35	0.098	13.76
Western Europe, group 2
FRANCE *	39	2.9	100	92	1	3	18	11	1.35	0.493	2.74
SWITZERLAND, Geneva	1	5.6	100	100	11	1	1	2	0.99	0.13	7.62
ITALY *	13	6.1	100	100	5	4	6	2	0.83	0.083	10.00
GERMANY, Saarland	4	1.3	100	75	13	3	1	0	0.73	0.083	8.75
THE NETHERLANDS, Eindhoven	5	6.3	100	100	0	0	2	0	0.67	0.076	8.86
Eastern Europe, group 3
SLOVAKIA	4	100	100	100	4	2	10	2	0.72	0.038	19.05
SLOVENIA	8	100	100	84	1	5	10	7	0.87	0.13	6.90
Norther Europe, group 4
NORWAY	18	100	100	89	10	8	18	4	1.11	0.132	8.39
Total	204	58	96	86	3	103	170	67	0.91	0.1	9.10

* regional cancer registries represented are East Anglia, Merseyside and Cheshire, Oxford, South Thames, Wessex, West Midlands, and Yorkshire (England); Calvados and Bas Rhin (France); and Florence, Latina, Turin, and Varese (Italy).

* Crude incidence rates; source: EUROCARE data set.

**Ratio between ethmoid (ICD9 1603) and all nasal cavities (ICD9 160) crude incidence rates.

Table II.  Relative survival (%) and relative excess risk of death (RER) with 95% confidence intervals (CI) of European patients diagnosed with ethmoid sinous adenocarcinoma in 1983–1994 by sex, age, diagnosis period, geographic grouping and stage.

	No. of patients	One-year survival (95% CI)	Three-year survival (95% CI)	Five-year survival (95% CI)	RER** (95% CI)
All	204	83.2 (76.9–88.1)	57.7 (49.9–64.9)	46.1 (38.1–53.9)
Sex
Male	174	82.3 (75.4–87.7)	56.9 (48.5–64.7)	46.4 (37.8–54.9)	1
Female	30	87.9 (68.7–96.5)	62.4 (41.3–78.8)	44.0 (24.2–63.7)	0.95 (0.53–1.72)
Age group (years)
< 55	56	82.5 (69.7–90.4)	56.2 (42.1–68.3)	46.7 (32.9–59.7)	1
55–64	62	83.5 (71.3–91.1)	65.9 (52.0–77.1)	59.5 (45.1–71.9)	0.69 (0.40–1.21)
65 +	86	83.3 (72.4–91.0)	52.0 (39.2–64.1)	33.0 (21.3–46.1)	1.26 (0.77–2.09)
Diagnosis period
1983–85	43	85.8 (70.6–94.2)	57.9 (40.7–72.5)	48.2 (31.2–64.3)	1
1986–88	58	80.1 (66.7–89.2)	55.3 (40.5–68.6)	41.1 (27.0–55.6)	1.29 (0.71–2.35)
1989–91	54	84.1 (70.5–92.5)	53.1 (37.9–66.8)	46.9 (31.4–62.2)	1.15 (0.63–2.12)
1992–94	49	83.3 (68.8–92.1)	65.4 (49.0–78.6)	49.1 (32.7–64.7)	1.06 (0.55–2.02)
Geographic grouping
UK (group 1)	112	80.2 (71.1–87.1)	57.4 (46.7–67.1)	41.2 (30.8–51.8)	1
Western Europe (group 2)	62	83.7 (71.5–91.3)	61.3 (47.3–73.0)	55.8 (41.3–68.9)	0.90 (0.54–1.51)
Slovenia and Slovakia (group 3)	12	85.2 (46.6–99.0)	41.1 (12.6–70.9)	22.4 (3.5–54.4)	1.62 (0.71–3.72)
Norway (group 4)	18	98.3 (69.4–100.0)	56.7 (29.4–79.4)	55.0 (26.4–80.9)	0.74 (0.32–1.71)
Stage
Localized	23	99.1 (74.6–100.0)	81.6 (55.1–97.3)	77.3 (48.7–97.3)
Regional	19	93.0 (66.6–100.0)	53.5 (27.6–76.1)	26.0 (8.1–50.7)
Metastatic	4	50.3 (5.8–85.0)	25.5 (0.9–67.8)	0.0 (0.0–0.0)
Unknown	158	80.6 (73.2–86.4)	56.5 (47.7–64.6)	45.5 (36.6–54.3)

*Variable not included in the multiple regression analisys; for stage definition see text.

**RER at 5 years from the multiple regression analysis.

Table III.  Comparison of 5-year survival for ethmoid sinous cancer in clinical series, SEER data and in Europe.

	No. of cases	Survival	Mean age
University Hospital of Bordeaux, 1975–2000	76	80	61
University of California-Los Angeles and Geneva University hospitals, 1975–1994*	47	48	57#
Danish Society for Head and Neck Oncology, 1982–1991 §	41	53	66#
SEER database, 1988–1998	23	55	60
UTMDACC, USA, 1969–1993	13	50	57
Present study, 1983–1994	204	46	61

na: information not available.

*All ethmoid sinus cancer.

§Adenocarcinoma of all sino-nasal cancers.

#Mean age of all sino-nasal cancers.