A validation of DCIS registration in a population-based breast cancer quality register and a study of treatment and prognosis for DCIS during 20 years

Figures & data

Figure 1. Selection of DCIS cases validated in the Uppsala-Örebro regional breast cancer register 1992–2012.

Table 1. Validation of primary DCIS data in the regional breast cancer registry compared to data from medical records in Uppsala-Örebro 1992–2012.

Register	Medical record		Proportion correct	Coverage
Mode of detection	Screening	Non- screening
Screening	183	13	94% (217/232)	88% (232/264)
Non-screening	2	34
Laterality	Right	Left
Right	139	2	99% (259/262)	99% (262/264)
Left	1	120
Tumor size	≥15 mm	<15 mm
≥ 15 mm	108	10	92% (194/212)	90% (237/264)*
< 15mm	8	86
Breast surgery	BCS	Mastectomy
BCS	176	6	95% (249/262)	99% (262/264)
Mastectomy	7	73
Axillary surgery	Yes	No
Yes	76	5	98% (258/264)	89% (76/85)
No	9	182
Radiotherapy	Yes	No
Yes	80	6	99% (261/264)	94% (80/85)
No	5	181

BCS: breast conserving surgery. *Tumor size was missing in the medical records of 14 patients registered and could therefore not be validated.

Table 2. Distribution of cases and tumor characteristics for patients registered with DCIS in Uppsala-Örebro 1992–2012 by time period.

	1992–1997	1998–2002	2003–2007	2008–2012	All patients	p-Value
Patients	693	628	835	796	2952	<0.001
Proportion DCIS of all breast cancer (%)	9.6%	8.6%	10.6%	9.2%	9.5%	0.22
Age (median, range)	56 (28–76)	57 (33–74)	58 (26–76)	60 (31–94)	58 (26–94)	0.96
Detected by mammography screening	462 (66.7%)	426 (67.8%)	542 (64.9%)	591 (74.3%)	2021 (68.5%)	<0.001
Nuclear grade
I	13 (72.2%)	15 (45.5%)	40 (23.7%)	78 (11.3%)		not done
II	3 (16.7%)	15 (45.5%)	85 (50.3%)	254 (36.9%)
III	2 (11.1%)	3 (9.1%)	44 (26.0%)	357 (51.8%)
DCIS size <15 mm	272 (39.3%)	287 (45.7%)	339 (40.6%)	235 (29.5%)	1133 (38.4%)	<0.001
≥15mm	252 (36.4%)	257 (40.9%)	449 (53.8%)	511 (64.2%)	1469 (49.8%)
Missing	169 (24.4%)	84 (13.4%)	47 (5.6%)	50 (6.3%)	350 (11.9%)

Table 3. Distribution of type of surgery and radiotherapy for patients registered with DCIS in Uppsala-Örebro 1992–2012 by time period.

	1992–1997	1998–2002	2003–2007	2008–2012	All patients	p-Value
Mastectomy	161 (23.2%)	150 (23.9%)	323 (38.7%)	313 (39.3%)	947 (32.1%)	<0.001
BCS	519 (74.9%)	468 (74.5%)	506 (60.6%)	476 (59.8%)	1969 (66.7%)
Missing	13 (1.9%)	10 (1.6%)	6 (0.7%)	7 (0.9%)	36 (1.2%)
BCS + RT	156/519 (30.0%)	178/468 (38.0%)	347/506 (68.6%)	322/476 (67.6%)	1003/1969 (51.0%)	<0.001

BCS: breast conserving surgery; RT: radiotherapy.

Figure 2. Reported ipsilateral recurrent breast events after breast conserving surgery with or without radiotherapy versus mastectomy for DCIS in the Uppsala-Örebro region 1992–2012.

Figure 3. Reported ipsilateral recurrent breast events after breast conserving surgery for DCIS with radiotherapy versus not in the Uppsala-Örebro region 1992–2012.

Figure 4. Relative survival, all registered DCIS in the Uppsala-Örebro region 1992–2012, by time period.