Langerhans cell histiocytosis of the sternum

Figures & data

Figure 1.  A lateral radiograph of the sternum showed an ill-defined osteolytic lesion in the sternum. Periosteal reactions around the lesion were also observed.

Figure 2.  Computed tomography (CT) showed an osteolytic lesion that dissolved both anterior and posterior cortex of the body of the sternum.

Figure 3.  Magnetic resonance imaging (MRI). The signal intensity of the tumor was low in the sternum on T1-weighted images (A) and high on T2-weighted images (B).

Figure 4.  Technetium bone scintigraphy reveals increased uptakes in the sternum, the greater trochanter of the right femur, and the right distal tibia.

Figure 5.  Radiographs show small and round osteolytic lesions (arrows) in the greater trochanter of the right femur (A) and the distal tibia (B).

Figure 6.  Histopathologic findings. Histopathologic examination reveals a proliferation of histiocytes with an infiltration of eosinophils. These histocytes were positive for S-100 (B), and for CD-1a (C). Original magnification ×400.

Table I.  Literature of sternal lesion of LCH.

Reference	Age	Gender	Lesions	Treatment
Wilson G J et al. (6)	6	F	Sternum only	Intralesional steroid
Sai S et al. (7)	25	F	Sternum only	Curettage
Fazio N et al. (8)	38	F	Sternum only	Partial sternectomy
Eroglu A at al. (9)	30	F	Sternum only	Partial sternectomy
Corti F et al. (10)	NS	NS	Sternum and other bones, skin	Radiotherapy and mecloretamin for skin lesion
Chiau JH et al. (11)	5	M	Sternum only	Curettage
Peer A et al. (12)	30	F	Sternum only	Radiotherapy and intralesional steroid
Gugliantini P et al. (13)	2	F	Sternum only	Chemotherapy

LCH = Langerhans cell histiocytosis; NS = not stated; F = female; M = male.