Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats

Figures & data

Table I.  Effect of aqueous extract of Andrographis paniculata (200 mg/kg) on serum creatinine, serum urea, blood urea nitrogen levels and urine volume in gentamicin-induced nephrotoxic rats.

Groups	Serum creatinine (µmol/L)	Serum urea (mmol/L)	Blood urea nitrogen (mmol/L)	Urine volume (L)
Normal	57.46±0.01	5.25±1.03	6.89±1.40	2.58×10^−3±0.11
Gentamicin control (80 mg/kg, i.p.)	170.61±0.30^a (196.92)	11.64±0.43^b (121.96)	23.54±0.63^b (241.65)	5.32×10^−3±0.20^b (106.20)
Extract-treated (200 mg/kg, p.o.)	68.95±0.10^c (20.00)	6.07±0.32^d (15.69)	9.56±0.16^d (38.75)	2.98×10^−3±0.50^c (15.50)
Statistics (one-way ANOVA)	F=15.607 (P<0.001)	F=44.690 (P<0.001)	F=42.977 (P<0.001)	F=23.622 (P<0.001)

Values are mean±SE (n=5). Data for normal animals are considered as base-line data; there was no significant base-line difference between the groups. Percentage increase (in parentheses) is calculated with reference to normal control.

^aP<0.01 versus control group.

^bP<0.001 versus control group.

^cP<0.01 versus gentamicin group.

^dP<0.001 versus gentamicin group.