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Review Article

Viral entry, lipid rafts and caveosomes

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Pages 394-403 | Published online: 08 Jul 2009

Figures & data

Table 1. Examples of molecules known to act as virus receptors.

Figure 1 Schematic presentation of viral endocytosis. Virus‐receptor interaction 1) gives rise to formation of virus‐containing membrane vesicles 2), which are internalized into the host cell 3). Subsequently, the viral core is released from these structures 4) by a fusion of the viral envelope and the cellular vesicular membrane or by a rupture of the endocytic vesicle.

Figure 1 Schematic presentation of viral endocytosis. Virus‐receptor interaction 1) gives rise to formation of virus‐containing membrane vesicles 2), which are internalized into the host cell 3). Subsequently, the viral core is released from these structures 4) by a fusion of the viral envelope and the cellular vesicular membrane or by a rupture of the endocytic vesicle.

Figure 2 Endocytosis of simian virus 40 and echovirus 1 to the caveosomes.A. Simian virus 40 is endocytosed into caveosomes via caveolae and caveolar vesicles. In some cell types the virus can enter the caveosomes directly from lipid rafts in non‐coated vesicles. Some of internalized SV40 particles can also be found in the endosomes. B. Echovirus 1 is internalized together with its receptor, α2β1 integrin, into caveosomes via cell surface caveolae or by an alternative pathway, which may originate from lipid rafts and does not involve clathrin‐coated pits. EV1 may remain in caveosomes prior to initiation of replication.

Figure 2 Endocytosis of simian virus 40 and echovirus 1 to the caveosomes.A. Simian virus 40 is endocytosed into caveosomes via caveolae and caveolar vesicles. In some cell types the virus can enter the caveosomes directly from lipid rafts in non‐coated vesicles. Some of internalized SV40 particles can also be found in the endosomes. B. Echovirus 1 is internalized together with its receptor, α2β1 integrin, into caveosomes via cell surface caveolae or by an alternative pathway, which may originate from lipid rafts and does not involve clathrin‐coated pits. EV1 may remain in caveosomes prior to initiation of replication.

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