Patients with Behcet's disease carry a higher risk for microvascular involvement in active disease period

Figures & data

Table I. Demographic, biochemical, and coronary flow measurements of the patients with Behcet's disease (BD) within inactive disease period and the control groups.

	BD patients in inactive disease period (n = 40; 18 female)	Controls (n = 45; 21 female)	P
Age (year)	35.5±10.5	38.1±7.9	0.18
BMI (kg/m^2)	24.4±3.7	25.4±3.5	0.22
Systolic BP (mmHg)	118.3±12.4	117.5±11.2	0.59
Diastolic BP (mmHg)	75.1±7.9	74.7±6.1	0.64
Heart rate (bpm)	72.8±5.2	78.1±9.8	0.003
Glucose (mmol/L)	5.1±0.4	5.0±0.4	0.18
Total cholesterol (mmol/L)	4.6±0.8	4.7±1.4	0.84
Triglyceride (mmol/L)	1.6±0.7	1.3±0.6	0.14
HDL (mmol/L)	1.1±0.2	1.1±0.2	0.45
LDL (mmol/L)	2.6±0.6	2.7±0.6	0.57
hsCRP (mg/dL)	3.77±6.01	2.03±1.51	0.056
ESR (mm/h)	10.65±7.41	11.12±6.58	0.51
Homocysteine (µmol/L)	12.04±12.28	10.02±9.8	0.16
Basal DPFV (cm/s)	24.6±7.5	23.6±3.6	0.42
Hyperemic DPFV (cm/s)	61.7±14.9	67.4±13.3	0.046
CFR	2.57±0.50	2.87±0.53	0.006
Mitral E/A ratio	1.48±0.31	1.33±0.30	0.052

BMI = body mass index; BP = blood pressure; CFR = coronary flow reserve; DPFV = coronary diastolic peak flow velocity; ESR = erythrocyte sedimentation rate; HDL = high‐density lipoprotein; hsCRP = high‐sensitivity C‐reactive protein; LDL = low‐density lipoprotein.

Table II. Comparison of coronary flow and echocardiographic measurements of patients with Behcet's disease (BD) while they were in the inactive and in the active disease period.

	BD patients in inactive disease period (n = 40)	BD patients in active disease period (n = 40)	P
Systolic BP (mmHg)	118.3±12.4	120.7±11.4	0.14
Diastolic BP (mmHg)	75.1±7.9	76.1±7.2	0.32
Heart rate (bpm)	72.8±5.2	73.4±4.8	0.51
hsCRP (mg/dL)	3.77±6.01	16.76±17.60	<0.001
ESR (mm/h)	10.65±7.41	22.31±15.22	<0.001
Basal DPFV (cm/s)	24.6±7.5	27.3±6.6	0.019
Hyperemic DPFV (cm/s)	61.7±14.9	56.8±16.7	0.015
CFR	2.57±0.50	2.09±0.46	<0.001
Mitral E/A ratio	1.48±0.31	1.31±0.29	0.004
Mitral deceleration time (ms)	187.2±27.8	203.9±31.6	0.007

BP = blood pressure; CFR = coronary flow reserve; DPFV = coronary diastolic peak flow velocity; ESR = erythrocyte sedimentation rate; hsCRP = high‐sensitivity C‐reactive protein.

Figure 1. Coronary flow reserve values of the controls and Behcet's disease (BD) patients while they were in inactive and in active disease period.