Autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease

Figures & data

Table I.  Characteristics of patients with celiac sprue (CS), ulcerative colitis (UC), or Crohn's disease (CrD).

	CS (n=117)	UC (n=90)	CrD (n=90)	P-value
Females, n (%)	93 (79.5)	32 (35.6)	43 (47.8)	<0.0001^a
Age (yrs):
Median	34.0	48.5	48.0	<0.0001^b
Range	18–78	18–80	20–81
Age at diagnosis (yrs):
Median	27.0	36	33	0.0003 ^b
Range	0–74	6–78	13–79
Age at symptom onset (yrs):
Median	17	34	27.5	<0.0001 ^b
Range	0–74	6–78	0–79
Time from symptom onset to diagnosis (yrs):
Median	2.5	0	1	<0.0001 ^b
Range	0–53	0–23	0–37

^a Chi-square test, 2 df.

^b Kruskall-Wallis test, 2 df.

Table II.  Prevalence of autoimmune (AI) diseases in patients with celiac sprue (CS), ulcerative colitis (UC), or Crohn's disease (CrD).

	CS (n=117)	UC (n=90)	CrD (n=90)
	n (%; 95% CI)	n (%; 95% CI)	N (%; 95% CI)
Total AI disease	30 (25.6; 18.0–34.5)	9 (10.0; 4.7–18.1)	19 (21.1; 13.2–31.0)
Onset of AI disease before intestinal disease	19 (16.2; 10.1–24.2)	5 (5.6; 1.8–12.5)	17 (18.8; 11.4–28.5)
Types of AI disease
Hashimoto's thyroiditis	8 (6.8; 3.0–13.0)	2 (2.2; 0.3–7.8)	4 (4.4; 1.2–11.0)
Alopecia areata	4 (3.4; 0.9–8.5)	1 (1.1; 0–6.0)	–
Psoriasis	4 (3.4; 0.9–8.5)	–	3 (3.3; 0.7–9.4)
Type 1 diabetes mellitus	3 (2.6; 0.5–7.3)	–	–
AI liver disorders	3 (2.6; 0.5–7.3)	1 (1.1; 0–6.0)	1 (1.1; 0–6.0)
Vitiligo	3 (2.6; 0.5–7.3)	1 (1.1; 0–6.0)	2 (2.2; 0.3–7.8)
Sjogren's syndrome	3 (2.6; 0.5–7.3)	1 (1.1; 0–6.0)	2 (2.2; 0.3–7.8)
Rheumatoid arthritis	2 (1.7; 0.2–6.0)	1 (1.1; 0–6.0)	3 (3.3; 0.7–9.4)
Idiopathic thrombocytopenic purpura	–	1 (1.1; 0–6.0)	2 (2.2; 0.3–7.8)
Pernicious/haemolytic anaemia	–	1 (1.1; 0–6.0)	2 (2.2; 0.3–7.8)
Others	–	–	–

95% CI=95% binomial confidence interval.