Baseline characteristics of participants in the Hypertension in the Very Elderly Trial (HYVET)

Figures & data

Table I. Reported characteristics and anthropometric measurements in men and women, by age group, at baseline in the Hypertension in the Very Elderly Trial (HYVET) study.

	Men				Women				Gender difference, p^a	Change with age, p^a
	All	80–84	85–89	90+	All	80–84	85–89	90+
Number	1519	1141	322	56	2326	1666	540	120
ISH patients (%)	31.8	33.0	28.9	23.2	32.9	33.7	31.1	29.2	0.48	0.07
Current smokers (%)	13.0	14.0	9.3	14.3	2.2	2.1	3.0	0.9	<0.001	0.08
Drink alcohol (%)	34.5	34.2	36.0	32.1	6.8	6.4	8.5	3.3	<0.001	0.49
Previous MI (%)	4.2	3.9	5.0	5.4	2.5	2.3	2.2	6.7	0.004	0.05
Previous CHF (%)	2.6	2.5	2.5	7.1	3.1	2.9	3.0	5.8	0.45	0.06
Previous hypertension (%)	90.0	89.0	92.9	92.9	89.8	89.6	90.6	89.2	0.82	0.14
Previous anti‐hypertensive treatment (%)	64.3	66.2	59.9	50.0	64.9	66.5	62.4	55.0	0.67	<0.001
Previous stroke (%)	8.9	9.6	6.5	7.1	5.4	5.9	4.4	3.3	<0.001	0.01
Previous CVD (%)	14.6	14.9	12.7	17.9	9.9	10.1	8.5	13.3	<0.001	0.74
Diabetes (%)	6.9	7.4	5.9	1.8	6.8	7.2	5.4	8.3	0.99	0.13
Weight (kg)	70.4	70.6	70.0	70.0	61.3	61.9	60.2	59.0	<0.0001	<0.0001
Height (cm)	169	169	169	169	157	157	157	156	<0.0001	0.07
BMI (kg/m2)	24.7	24.7	24.6	24.4	24.7	24.9	24.2	24.1	0.59	<0.0001

^aGender p‐values adjusted for age and vice versa. ISH, Isolated systolic hypertension; MI, Myocardial infarction; CHF, Congestive heart failure; CVD, Cardiovascular disease; BMI, Body mass index.

Table II. Blood pressure and biochemical measurements in men and women, by age group, at baseline in the Hypertension in the Very Elderly Trial (HYVET) study.

	Men				Women				Gender difference, p^a	Change with age, p^a
	All	80–84	85–89	90+	All	80–84	85–89	90+
Sitting SBP (mmHg)	172	172	172	173	174	173	174	174	<0.0001	0.07
Sitting DBP (mmHg)	90.9	90.8	91.0	91.5	90.7	90.7	90.6	90.6	0.53	0.47
Standing SBP (mmHg)	167	167	167	166	169	169	169	168	<0.0001	0.91
Standing DBP (mmHg)	88.7	88.8	88.5	88.8	88.6	88.7	88.4	88.7	0.82	0.32
Pulse rate (1 min)	74.0	74.2	73.6	72.6	74.8	74.9	74.5	75	<0.01	0.23
Total cholesterol (mmol/l)	5.15	5.11	5.21	5.51	5.39	5.39	5.37	5.39	<0.001	0.17
HDL‐cholesterol (mmol/l)	1.32	1.33	1.30	1.28	1.37	1.37	1.35	1.38	0.0006	0.24
Glucose (mmol/l)	5.46	5.49	5.39	5.21	5.39	5.43	5.33	5.22	0.24	0.013
Fasting glucose (mmol/l)	5.47	5.51	5.37	5.20	5.37	5.40	5.35	5.17	0.092	0.038
Urea (mmol/l)	6.47	6.41	6.69	6.46	6.20	6.19	6.20	6.39	<0.0001	0.11
Creatinine (μmol/l)	93.5	92.7	96.0	96.8	85.9	84.9	88.2	89.4	<0.0001	0.0001
Uric acid (μmol/l)	299	298	300	305	267	266	271	266	<0.0001	0.64
Potassium (mmol/l)	4.36	4.35	4.38	4.44	4.33	4.33	4.34	4.34	0.058	0.0037
Sodium (mmol/l)	142	142	142	142	141	141	142	142	0.47	0.011
Haemoglobin (g/dl)	13.8	13.8	13.7	13.3	12.7	12.8	12.7	12.6	<0.0001	0.0145
Haematocrit (%)	41.4	41.5	41.3	39.9	38.9	38.8	39.1	39.2	<0.0001	0.26

SBP, Systolic blood pressure; DBP, Diastolic blood pressure; HDL, High‐density lipoprotein. ^aGender p‐values adjusted for age and vice versa.

Table

	Previous CVD
	Women		Men		CVD effect
	Yes	No	Yes	No	p^a
Number	231	2095	221	1298
ISH patients (%)	38.1	33.3	33.0	31.6	0.13
Current smokers (%)	3.5	2.1	11.3	13.3	0.46
Drink alcohol (%)	5.6	6.9	28.5	35.5	0.59
Previous anti-hypertensive treatment (%)	74.9	63.8	75.1	62.4	<0.001
Diabetes (%)	13.0	6.2	12.7	5.9	<0.001
Weight (kg)	62.2	61.3	71.5	70.3	0.052
Height (cm)	157	157	168	169	0.12
BMI (kg/cm^2)	25.3	24.6	25.2	24.6	0.001
Blood Pressure
Sitting SBP (mmHg)	172	174	171	172	0.0001
Sitting DBP (mmHg)	89.7	90.8	90.4	91.0	0.047
Standing SBP (mmHg)	167	169	164	167	<0.0001
Standing DBP (mmHg)	87.7	88.8	88.1	88.8	0.050
Pulse rate (1 min)	76.1	74.7	74.0	74.0	0.10
Total cholesterol (mmol/l)	5.58	5.36	5.25	5.13	0.0025
HDL‐cholesterol (mmol/l)	1.36	1.37	1.30	1.33	0.45
Glucose (mmol/l)	5.65	5.37	5.48	5.45	0.026
Fasting Glucose(mmol/l)	5.64	5.34	5.47	5.47	0.037
Urea (mmol/l	6.2	6.2	6.8	6.4	0.021
Creatinine (μmol/l)	86.4	85.9	95.8	93.1	0.12
Uric acid (μmol/l)	287	265	322	295	<0.0001
Potassium (mmol/l)	4.3	4.3	4.3	4.4	0.037
Sodium (mmol/l)	141	141	141	142	0.058
Haemoglobin (g/dl)	12.9	12.7	13.8	13.8	0.07
Haematocrit (%)	39.0	38.9	41.3	41.4	0.96

Abbreviations as in Tables I and II. ^a Effects of CVD adjusted for gender differences.