Acute Renal Failure and Hypercalcemia

Figures & data

Table 1 Age, gender, diagnosis and treatment of eight patients with hypercalcemia and renal failure

Patient	Gender	Age	Diagnosis	Treatment
1	M	65	Multiple myeloma	DH + CT
2	M	85	Multiple myeloma	DH + CT + calcitonin
3	M	60	Non-Hodgkin's lymphoma	DH + CT + calcitonin
4	F	28	Mediastinal tumor	DH + CT
5	F	77	Hyperparathyroidism	DH
6	M	44	Sarcoidosis	DH + corticotherapy
7	F	62	Intoxication by vitamin D	DH + vitamin D withdrawal
8	M	39	Leprosy	DH + calcitonin + dapsone + clofazimine

DH, diuretics + hydration; CT, chemotherapy.

Table 2 Maximum creatinine and ionized and total calcium values before and after treatment

Patient	Maximum serum creatinine levels (mg/dL)	Serum creatinine after treatment (mg/dL)	Maximum total serum calcium levels (mg/dL)	Total serum calcium after treatment (mg/dL)	Maximum serum ionized calcium levels (mmol/L)	Serum ionized calcium after treatment (mmol/L)	Improvement of renal function(days)
1	3.9	2.5	19.9	NA	2.03	1.09	10
2	2.6	0.9	13.2	8.4	2.22	1.03	08
3	3.2	1.1	19.9	9.6	2.43	1.21	11
4	2.1	0.8	19.7	8.3	2.2	1.10	12
5	3.8	1.2	13.8	9.6	1.62	1.22	07
6	6.0	1.5	15.4	8.5	1.57	1.05	14
7	3.5	0.9	16.5	9.9	2.2	1.19	10
8	2.9	1.2	12.7	9.1	2.1	1.24	11
^†	3.3 (2.7, 3.8)	1.1 (0.9, 1.3)	15.9 (13.5, 19.8)	9.1 (8.4, 9.7)	2.1 (1.8, 2.2)	1.1 (1.0, 1.2)	10.5 (9.0, 11.5)

*died.

^†Data are expressed as median and percentile (25th, 75th).

NA, not available.

Figure 1. Serum creatinine levels before and after treatment of hypercalcemia. The horizontal lines represent the medians. The line drawn for creatinine levels represents the upper limit of normal serum creatinine levels (1.3 mg/dL).

Figure 2. Total serum calcium levels (top) and ionized serum calcium levels (bottom) before and after treatment of hypercalcemia. The horizontal lines represent the medians. The lines drawn for total and ionized serum calcium represent the upper limit of normal laboratory levels (10.1 mg/dL and 1.32 mmol/L, respectively).