Predictive Factors for Chronic Renal Failure One Year after Orthotopic Liver Transplantation

Figures & data

Figure 1 The outcome of creatinine clearance at M12 according to pre-OLT creatinineclearance.

Figure 2 The outcome of creatinine clearance at M12 according to the occurrence of acute renal dysfunction within the first month post-OLT, be it mild (RIFLE score ≥2) or severe (RIFLE score ≥3).

Table 1 Factors associated in the univariate analysis with the development of chronic renal failure at one-year post-liver transplantation

Variables	OR (CI)	p value
Age >50 years	4.3 (1.44–12.65)	0.006
Sex: women/men	5.67 (1.8–18.1)	0.002
Liver disease: hepatitis C	3.8 (1.2–12.6)	0.019
Pre-OLT creatinine clearance<80 mL/min	9.3 (2.7–32.1)	0.0001
Serum creatinine at D3 (>130 μmol/L)	4.85 (1.59–14.77)	0.004
Serum creatinine at M1 (>130 μmol/L)	3.98 (1.11–14.25)	0.027
Serum creatinine at M3 (>130 μmol/L)	3.77 (1.16–12.25)	0.022
Serum creatinine at M6 (>130 μmol/L)	7.29 (2.1–25.22)	0.0007

OR: odds ratio; CI: confidence interval; D: day; M: month; OLT: orthotopic liver transplantation

Table 2 Factors associated in the multivariate analysis with the development of chronic renal failure at post-liver transplantation

Variables	OR (CI)	p value
Female sex	11.5 (2.3–58.3)	0.003
Liver disease: hepatitis C	5.01 (1.1–22.7)	0.03
Pre-OLT creatinineclearance <80 mL/min	5.4 (1.2–23.7)	0.025
Serum creatinine at M6 (>130 μmol/L)	19.6 (3.7–102.5)	0.0004

OR: odds ratio; CI: confidence interval; M: month; OLT: orthotopic liver transplantation