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LABORATORY STUDY

Melatonin Reduces Nitric Oxide via Increasing Arginase in Rhabdomyolysis-Induced Acute Renal Failure in Rats

, Ph.D., , Ph.D., , M.D., , M.D. & , Ph.D.
Pages 435-440 | Published online: 07 Jul 2009

Figures & data

Figure 1 Kidney tissue arginase activities in SHAM, ARF, ARF-M5, and ARF-M10 groups: (a) the comparison between SHAM and ARF, (b) the comparison between ARF and ARF-M5, (c) the comparison between ARF and ARF-M10, (d) the comparison between groups (*p < 0.05, **p < 0.01, and ***p < 0.001). SHAM: Sham control; ARF: Acute renal failure treated with saline; ARF-M5: Acute renal failure treated with melatonin (5 mg/kg); ARF-M10: Acute renal failure treated with melatonin (10 mg/kg).

Figure 1 Kidney tissue arginase activities in SHAM, ARF, ARF-M5, and ARF-M10 groups: (a) the comparison between SHAM and ARF, (b) the comparison between ARF and ARF-M5, (c) the comparison between ARF and ARF-M10, (d) the comparison between groups (*p < 0.05, **p < 0.01, and ***p < 0.001). SHAM: Sham control; ARF: Acute renal failure treated with saline; ARF-M5: Acute renal failure treated with melatonin (5 mg/kg); ARF-M10: Acute renal failure treated with melatonin (10 mg/kg).

Figure 2 Kidney tissue ornithine levels in SHAM, ARF, ARF-M5, and ARF-M10 groups: (a) the comparison between SHAM and ARF, (b) the comparison between ARF and ARF-M5 groups (**p < 0.01 and ***p < 0.001). SHAM: Sham control; ARF: Acute renal failure treated with saline; ARF-M5: Acute renal failure treated with melatonin (5 mg/kg); ARF-M10: Acute renal failure treated with melatonin (10 mg/kg).

Figure 2 Kidney tissue ornithine levels in SHAM, ARF, ARF-M5, and ARF-M10 groups: (a) the comparison between SHAM and ARF, (b) the comparison between ARF and ARF-M5 groups (**p < 0.01 and ***p < 0.001). SHAM: Sham control; ARF: Acute renal failure treated with saline; ARF-M5: Acute renal failure treated with melatonin (5 mg/kg); ARF-M10: Acute renal failure treated with melatonin (10 mg/kg).

Figure 3 Kidney tissue NO levels in SHAM, ARF, ARF-M5, and ARF-M10 groups: (a) the comparison between SHAM and ARF; (b) the comparison between ARF and ARF-M5 groups; (c) the comparison between ARF and ARF-M10 (***p < 0.001). SHAM: Sham control; ARF: Acute renal failure treated with saline; ARF-M5: Acute renal failure treated with melatonin (5 mg/kg); ARF-M10: Acute renal failure treated with melatonin (10 mg/kg).

Figure 3 Kidney tissue NO levels in SHAM, ARF, ARF-M5, and ARF-M10 groups: (a) the comparison between SHAM and ARF; (b) the comparison between ARF and ARF-M5 groups; (c) the comparison between ARF and ARF-M10 (***p < 0.001). SHAM: Sham control; ARF: Acute renal failure treated with saline; ARF-M5: Acute renal failure treated with melatonin (5 mg/kg); ARF-M10: Acute renal failure treated with melatonin (10 mg/kg).

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