Acute Effect of Standard Heparin Versus Low Molecular Weight Heparin on Oxidative Stress and Inflammation in Hemodialysis Patients

Figures & data

Table 1 Characteristics of treatment and control groups

	Group 1 (n = 11)	Group 2 (n = 11)	Group 3 (n = 11)
Age (years)	48 ± 5	52 ± 5.2	51.2 ± 5.7
Gender (men/women)	6/5	7/4	6/5
Time on dialysis (month)	37.5 ± 6.5	44 ± 9.7	45.2 ± 10.5
Mean arterial blood pressure (mmHg)	78.5 ± 5.1	87.5 ± 6.1	78.2 ± 4.4
Dry weight (kg)	59.9 ± 3	58.2 ± 3.5	58.2 ± 3.1
Cardiothoracic ratio (%)	47.2 ± 1.4	48.2 ± 1.2	47 ± 1.5
Serum albumin (g/dL)	4.0 ± 0.1	4.2 ± 0.1	4.1 ± 0.1
Ferritin (ng/mL)	557.3 ± 69.4	539 ± 60.1	559.1 ± 69.7
Kt/Vüre	1.30 ± 0.02	1.25 ± 0.02	1.3 ± 0.02
Parathyroid hormone (ng/mL)	326.8 ± 26.6	255.2 ± 18.3	283.4 ± 27.5
Renal disease
Glomerulonephritis	5	5	5
Interstitial nephropathy	2	1	2
Hypertensive nephropathy	3	3	3
Diabetic nephropathy	1	1	1
Polycystic kidney disease	—	1	—

Table 2 Laboratory values of groups

	Group 1 (SH)		Group 2 (LMWH)		Group 3 (Control)
Parameters	Before	After	Before	After	Before	After
CRP (mg/L)	4.4 ± 0.8	5.6 ± 1.1	4.8 ± 0.9	5.4 ± 0.6^†	4.8 ± 1.4	5.7 ± 1.5
TNF α (pg/mL)	3.4 ± 0.37	4.8 ± 0.4	3.4 ± 0.9	4.3 ± 0.7^†	3.7 ± 0.6	5.4 ± 0.5
SOD (U/gHb)	345.2 ± 17.4	305.6 ± 17.3	345.3 ± 11.6	360 ± 6.9^†	341.1 ± 13.9	297.1 ± 11.1
MDA (μmol/mL)	0.49 ± 0.04	0.63 ± 0.05	0.50 ± 0.03	0.53 ± 0.04^†	0.52 ± 0.06	0.71 ± 0.07

*p < 0.05, ^†p > 0.05, before vs. after.

Figure 1 Serum CRP and MDA values of group 1 (SH) and group 2 (LMWH). Solid lines indicate group 1, dotted lines indicate group 2 (p < 0.05 in group 1, p > 0.05 in group 2, for both CRP and MDA).