Kikuchi-Fujimoto Disease and Systemic Lupus Erythematosus: The EBV Connection?

Figures & data

Table 1 Laboratory results on admission and the fifth day

	On admission	Day 5
Blood
WBC (/mm^3)	3400	2980
WBC type	71/24/5	67/23/9/1
Hb (g/dL)	7.1	10.3
PLT (/mm^3)	170,000	106,000
ESR (mm/hr)	120	60
PT/INR	11.4/0.94	11/0.9
APTT	22.3	28.6
Fibrinogen/FDP	3.74/>20	1.91/15.15
Glucose (mg/dL)	102	78
BUN (mg/dL)	31	79
Creatinine (mg/dL)	1.44	2.36
sGOT/sGPT (IU/L)	30/34	44/46
γGT/ALP (IU/L)	21/44	33/49
Chelerythrine (mg/dL)	0.34	0.34
Protein/albumin (g/dL)	6.3/2.7	5.5/2.8
K/Na (mEq/L)	4.5/141	3.7/137
Ca/P (mEq/L)	7.7/5.0	7.6/3.8
LDH (IU/L)	368	339
Uric acid (mg/dL)	6.7	6.3
Urine
Urine volume (mL/24h)	1400	2400
RBCs (/h.p.f.)	100–150	100–150
WBCs (/h.p.f.)	15–20	3–5
Albumin (g/24h)	8	9.8
Creatinine clearance (mL/min)	65.7	75
Immunologic
ANA		1:160
Anti-DNA		1:80
Anti-Sm		Neg
Anti-SSA /anti-SSB(IU/mL)		117.7/30.6
Anti-RNP (IU/mL)		116.5
Anti-cardiolipin		Neg
ANCA		Neg
C3/C4 (mg/dL)		21.7/6.2
HBsAg	Neg
Anti-HCV	Neg
Anti-HIV	Neg

Figure 1. Cervical lymph node showing areas of tissue necrosis with extensive apoptosis and abundant nuclear debris but no leukocytic infiltration (H+E stain).

Figure 2. Prominent histiocytic proliferation in cervical lymph node (positive CD68 expression-peroxidase stain).

Figure 3. Renal tissue section showing marked global endocapillary and mesangial proliferation with scattered polymorphonuclear infiltrates. Several capillaries contain eosinophilic intraluminal deposits that form hyaline thrombi (H+E stain).