Lipid Peroxidation Products Formation with Various Intravenous Iron Preparations in Chronic Kidney Disease

Figures & data

Table 1 Baseline characteristics of patients

	ID	SFGC	IS	p value
Number of patients (n)	19	20	20	NS
Age (years)	45 ± 5.6	43 ± 4.9	46 ± 5.9	NS
Males	12	14	15	NS
Weight (kgs)	58.1 ± 3.4	56.2 ± 2.6	57.2 ± 2.9	NS
BMI (kg/m^2)	20.1 ± 1.4	21.3 ± 1.3	19.2 ± 1.6	NS
Smokers	6	8	7	NS
Prior history of coronary artery disease	1	1	2	NS
Diabetic nephropathy	5	6	5	NS
Chronic glomerulonephritis	10	11	12	NS
Hypertensive nephrosclerosis	2	2	2	NS
Other causes of CKD	1	1	1	NS
Systolic blood pressure (mmHg)	141.1 ± 2.3	139.2 ± 5.4	149.4 ± 11.4	NS
Diastolic blood pressure (mmHg)	89.2 ± 3.4	90.2 ± 4.8	90.8 ± 4.2	0.045
Number of patients on ACE inhibitors and angiotensin receptor blockers	10	10	12	NS
Number of patients on epoietin	14	16	15	NS
Hemoglobin (g/dL)	10.3 ± 1.3	9.8 ± 2.4	9.9 ± 2.8	NS
Transferrin saturation (TSAT, in %)	21 ± 3.5	20.3 ± 2.3	19.7 ± 3.8	NS
Serum ferritin (ng/mL)	85.6 ± 2.4	88.4 ± 2.7	89.3 ± 3.7	NS
Serum albumin (g/dL)	3.2 ± 1.5	3.0 ± 1.9	3.1 ± 1.8	NS
Serum cholesterol (mg/dL)	189.2 ± 2.4	190.3 ± 3.5	210 ± 15.8	NS
Low-density lipoprotein (LDL) cholesterol (mg/dL)	104 ± 3.8	110 ± 2.6	105 ± 2.8	NS
Number of patients on statins	7	8	6	NS

Abbreviations: NS = nonsignificant, BMI = body mass index, ACE = angiotensin-converting enzyme, ID = iron dextran, SFGC = sodium ferrigluconate complex, IS = iron sucrose.

Table 2 Plasma malondialdehyde levels among the three groups

	ID (n = 19)	SFGC (n = 20)	IS (n = 20)	ID vs. SFGC (p value)	SFGC vs. IS (p value)	ID vs. IS (p value)
Pre-infusion pMDA (μMol/L)	1.89 ± 0.21	1.74 ± 0.32	1.83 ± 0.21	NS	NS	NS
Post-infusion pMDA(μMol/L)	2.92 ± 0.20	3.12 ± 0.84	2.82 ± 0.44	0.048	0.034	NS
Pre-infusion vs. post-infusion pMDA (p value)	<0.001	<0.001	<0.001	—	—	—

*test applied Wilcoxon signed rank test.

^†test applied Kruskal Wallis test.

Abbreviations: ID = iron dextran, SFGC = sodium ferrigluconate complex, IS = iron sucrose, pMDA = plasma malondialdehyde, NS = nonsignificant (p < 0.05 is significant).

Table 3 Correlations with post-transfusion plasma malondialdehyde levels

Variable	Correlation coefficient	p value
Hemoglobin (g/dL)	0.021	NS
TSAT (%)	0.058	NS
Serum ferritin (ng/mL)	0.012	NS
Serum creatinine (mg/dL)	0.321	NS
Serum cholesterol (mg/dL)	0.125	NS

Abbreviations: TSAT = percentage transferrin saturation (%); NS = nonsignificant.