Health-Related Quality of Life, Treatment Efficacy, and Hemodialysis Patient Outcome

Figures & data

Table 1 Characteristics of the examined population (n = 102) at the onset of the study

Age (years)	55.4 ± 13.8 (21–82)
Gender (n, M/F)	47/55
Dialysis duration (months)	81.4 ± 55.5 (11–231)
Hemoglobin (g/L)	86.5 ± 15.6
Serum albumin (g/L)	38.8 ± 3.7
Serum total cholesterol (g/L)	4.8 ± 1.2
Serum triglycerides (g/L)	2.3 ± 1.4
Serum CRP (mg/L)	8.2 ± 9.9
Serum creatinine (umol/L)	957.9 ± 186.8
Kt/V	1.2 ± 0.22
nPCR (g/kg/day)	1.1 ± 0.27
Body mass index (kg/m^2)	22.5 ± 3.7
On treatment with EPO (n)	25
Physical health	46.1 ± 23.3
Mental health	59.5 ± 21.7
Kidney disease target issues	60.1 ± 18.3
Patient satisfaction	75.9 ± 20.0

Data are given as mean ± standard deviation.

Abbreviations: EPO = erythropoietin, CRP = C-reactive protein; Kt/V = fractional urea clearance.

Table 2 Age, hemodialysis duration, serum hemoglobin concentration, dialysis adequacy, and four HrQoL dimensions patients in 2001, 2004, and 2007

Parameters	2001	2004	2007	p
Age (years)	55.4 ± 13.8	54.3 ± 11.0	57.0 ± 13.5	ns
Hemodialysis duration (months)	81.4 ± 55.5	96.3 ± 59.4	121.4 ± 64.4	0.000
Hemoglobin (g/L)	86.5 ± 15.6	106.6 ± 18.7	115.6 ± 19.7	0.000
Kt/V	1.2 ± 0.22	1.37 ± 0.19	1.56 ± 0.22	0.000
Physical health	46.1 ± 23.3	51.3 ± 12.9	46.1 ± 15.2	ns
Mental health	59.5 ± 21.7	65.8 ± 14.7	62.4 ± 12.5	ns
Kidney disease target issues	60.1 ± 18.3	61.5 ± 17.2	65.7 ± 14.9	ns
Patient satisfaction	75.9 ± 20.0	74.0 ± 17.0	75.5 ± 20.5	ns

Data are given as mean ± standard deviation.

*p = ANOVA.

Abbreviations: Kt/V = fractional urea clearance, ns = non-significant.

Figure 1. The scores of SF36 domains for examined patients in 2001, 2004 and 2007. *p < 0.05. Abbreviations: PF = physical functioning, RF = role limitation due to physical health, P = pain, GH = general health perception, EWB = emotional well-being, RE = role limitation due to emotional problems, SOF = social function, EF = energy/fatigue.

Figure 2. The scores of the kidney disease target domains for examined patients in 2001, 2004, and 2007. *p < 0.05. Abbreviations: SP = symptoms/problems, EKD = effects of kidney disease, BKD = burden of kidney disease, WK = work status, CF = cognitive function, QSI = quality of social interactions, S = sexual function, S = sleep, SS = social support, DSE = perception of dialysis staff encouragement, PS = patient satisfaction.

Table 3 Predictors of mortality: multivariate Cox proportional hazard model

Variable	β	Hazard ratio (CI)	p
Age	0.061	1.063 (1.019–1.108)	0.005
Kidney disease target issues (KDI)	−0.032	0.969 (0.941–0.998)	0.034

Figure 3. Kaplan-Meier estimate of survival in hemodialysis patients divided into groups in relationship to the kidney disease target issue dimension (KDI) scores.