Asymmetric dimethylarginine compartmental behavior during high-flux hemodialysis

Figures & data

Table 1. Patient demographics and hemodialysis characteristics.

Parameters	Result
Age (years)	50.71 ± 9.80
Sex (M/F)	8:0
BMI (kg/m^2)	22.21 ± 3.24
Hemoglobin (g/l)	141.42 ± 25.88
Hematocrit (%)	41.97 ± 8.46
Albumin (g/l)	41.81 ± 1.58
HD vintage (months)	128.86 ± 32.86
Body weight postdialysis (kg)	65.66 ± 10.13
Ultrafiltration Rate (ml/h)	753.50 ± 119.40
spKt/V	1.54 ± 0.18

BMI: body mass index; HD: hemodialysis.

Table 2. Plasma and erythrocyte concentration at different times during and after dialysis.

	Plasma concentration (mg/l)			Erythrocyte concentration (mg/l)
	BUN	Cr	ADMA	BUN	ADMA
0 min	804 ± 148	135 ± 24	0.243 ± 0.056	840 ± 149	0.73 ± 0.12
30 min Inlet	594 ± 121*	102 ± 20*	0.206 ± 0.053	642 ± 130*	0.69 ± 0.11
Outlet	65 ± 16^*†	17 ± 4^*†	0.044 ± 0.016^*†	251 ± 65^*†	0.70 ± 0.10
60 min Inlet	495 ± 108*	86 ± 18*	0.182 ± 0.047*	513 ± 141*	0.68 ± 0.10
Outlet	55 ± 17^*†	14 ± 4^*†	0.041 ± 0.014^*†	236 ± 65^*†	0.71 ± 0.11
120 min Inlet	387 ± 115*	68 ± 16*	0.173 ± 0.042*	402 ± 116*	0.66 ± 0.07
Outlet	44 ± 14^*†	12 ± 5^*†	0.029 ± 0.014^*†	209 ± 58^*†	0.64 ± 0.08*
240 min Inlet	228 ± 59*	49 ± 13*	0.163 ± 0.041*	335 ± 68*	0.65 ± 0.10
Outlet	28 ± 9^*†	11 ± 6^*†	0.037 ± 0.014^*†	202 ± 41^*†	0.64 ± 0.05*
Postdialysis 1 h	250 ± 67*	55 ± 13*	0.210 ± 0.049	366 ± 80*	0.67 ± 0.08
Postdialysis 48 h	729 ± 117	130 ± 16	0.219 ± 0.065	764 ± 171	0.72 ± 0.08

*p < 0.05 compared with predialysis concentrations; ^†p < 0.05 compared with plasma inlet concentrations in respective time course. BUN: urea nitrogen; Cr: creatinine; ADMA: asymmetric dimethylarginine.

Table 3. Reduction Ratio (RR) and effective reduction ratio (RR_eff) for the different compounds (corrected for hemoconcentration).

Compound	MW (D)	RR (%)	RReff (%)
BUN	60	75.5 ± 1.99	71.33 ± 2.38^‡
Cr	113	70.13 ± 4.38	67.41 ± 4.52*
ADMA	202	37.21 ± 6.44^*†	17.60 ± 5.50^*†‡

*p < .05 compared with BUN. ^†p < .05 compared with Cr. ^‡p < .05 compared with RR. BUN: urea nitrogen; Cr: creatinine; ADMA: asymmetric dimethylarginine;

MW: molecule weight; RR: reduction ratio; RR_eff: effective reduction ratio.

Figure 1. The mean solute levels of plasma ADMA and urea throughout the course of HD, 60 min postdialysis and prior to the next HD treatment (values are expressed as a fraction of the predialysis, initial plasma level). *p < .05 compared with the initial fraction of the predialysis level.

Figure 2. Time course of plasma ADMA/creatinine ratios during HD, 60 min postdialysis and prior to the next HD treatment. *p < .05 compared with the initial fraction of the predialysis level.