Figures & data
Figure 2. Mitochondrial alterations in a mouse model of PF. To determine the effect of PF on mitochondrial morphology, we observed the mitochondrial changes in PMCs in parietal peritoneal tissue using TEM. Typical TEM images are displayed (magnification ×15,000). PMCs: peritoneal mesothelial cells; TEM: transmission electron microscopy; PF: peritoneal fibrosis; PF + Met: peritoneal fibrosis + metformin; PF + PGC-1α: peritoneal fibrosis + PGC-1α overexpression; PF + Vector: peritoneal fibrosis + empty adenoviral vector.
Figure 4. Activation of the AMPK-PGC-1α pathway inhibited the apoptosis of PMCs. The apoptosis of PMCs in parietal peritoneal tissue was revealed using a TUNEL assay. Representative images are displayed (magnification ×400). Quantitative analysis of TUNEL-positive cells. The results are representative of three independent experiments. *p < 0.05 vs. Control. #p < 0.05 vs. PF. PMCs: peritoneal mesothelial cells; TUNEL: TdT-mediated dUTP nick-end labeling; PF: peritoneal fibrosis; PF + Met: peritoneal fibrosis + metformin; PF + PGC-1α: peritoneal fibrosis + PGC-1α overexpression; PF + Vector: peritoneal fibrosis + empty adenoviral vector.
Data availability statement
The data that support the findings of current study are available from the corresponding author upon reasonable request.