https://orcid.org/0000-0002-8139-5758
Figures & data
Figure 1. Patient pedigree diagram: The black squares and circles with corresponding numbers represent 5 patients of LPG (Case 5,7,9,10,11) who had clear family histories diagnosed in our hospital. Two patients from Yinchuan (Case 9,10) were mother and son. One patient from Xinjiang (Case 11), whose mother was also an LPG patient, and the patient from Yinchuan (Case 10) were cousins. Two patients (Case 5 and 7) from Cangzhou were cousins. The two black squares without numbers represent patients of LPG diagnosed in other hospitals. The square with oblique line represents a person who has passed away.
Table 1. General data and prognosis of the patients.
Table 2. Laboratory examination results.
Figure 2. Light microscopy: Eosin staining showed dilated capillary loops exhibiting an eosinophilic lipoprotein thrombus inside the capillary lumens.
Figure 3. Light microscopy: Oil red O staining showed large amounts of red droplets in the thrombus-like substances in the renal specimen.
Figure 4. Electron microscopy: Proliferative lesions of mesangial matrix (4 A) and mesangial cells (4B) were observed in the renal specimen.
Figure 5. Light microscopy: Proliferation of mesangial cells and matrix was observed in the renal specimen.
Figure 6. Electron microscopy: Irregular thickening of the basement membrane and segmental double-track formation was observed in the renal specimen.
Figure 7. Electron microscopy: Renal tubular lesions including vacuolization (red arrows), granular degeneration (white arrows) and focal atrophy (yellow arrows) of epithelial cells were observed in the renal specimen.
Figure 8. Electron microscopy: Dilated glomerular capillary lumens were filled with a large number of particles of different sizes and electron densities.
Figure 9. Electron microscopy: Vacuoles were observed in the glomerular capillary lumen.
Figure 10. Electron microscopy: The basement membrane showed insect eroding and tear-like changes.
Table 3. Immunofluorescence staining.
Table 4. APOE gene mutations.
Table 5. Laboratory examination results before and after treatment.
Supplemental Material
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