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Autoimmunity Volume 56, 2023 - Issue 1
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Research Article

Potential significance of changes in serum levels of IL-17, TNF-α and DKK-1 in the progression of the rheumatoid arthritis

Qunxia Wanga Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-1394-8303View further author information
ORCID Icon,
Yanzhao Liua Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Jiazhen Wua Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Simei Chena Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Tingting Hua Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Yuhan Liua Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Xu Lia Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Xiaohang Lia Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Yang Wua Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Jianlin Yua Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Tingting Zengb Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Yi Luoc The Second Affiliated Hospital of Jiangxi, University of Chinese Medicine, Nanchang, Jiangxi, People’s Republic of ChinaView further author information
,
Xiaoyan Hua Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaCorrespondence[email protected]
View further author information
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Li-Ming Tana Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province’s Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Article: 2276068 | Received 26 Mar 2023, Accepted 21 Oct 2023, Published online: 01 Nov 2023

Figures & data

Table 1. Basic information of each group.

Figure 1. Comparison of the expression levels of serum IL-17, TNF-α and DKK-1 in each group, **p < 0.001; *p < 0.05.

Figure 1. Comparison of the expression levels of serum IL-17, TNF-α and DKK-1 in each group, **p < 0.001; *p < 0.05.

Figure 2. Correlation of serum IL-17, TNF-α and DKK-1 with clinical data.

Figure 2. Correlation of serum IL-17, TNF-α and DKK-1 with clinical data.

Figure 3. Relationship between DAS28 scores and the expression levels of IL-17, TNF-α and DKK-1 in RA.

Figure 3. Relationship between DAS28 scores and the expression levels of IL-17, TNF-α and DKK-1 in RA.

Figure 4. The ROC curve for each indices to diagnose RA.

Figure 4. The ROC curve for each indices to diagnose RA.

Table 2. Clinical evaluation of research indices.

Figure 5. ROC Curves of IL-17, TNF-α and DKK-1 for the diagnosis of moderate to high activity RA.

Note: ROC, subject operating characteristic curve.

Figure 5. ROC Curves of IL-17, TNF-α and DKK-1 for the diagnosis of moderate to high activity RA.Note: ROC, subject operating characteristic curve.

Table 3. Clinical evaluation of IL-17, TNF-α and DKK-1 in the diagnosis of moderate to high activity RA.

Data availability statement

The data that support the fundings of this study are availability from the corresponding author [QW], upon reasonable request.

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