Figures & data
Figure 1. Noni fruit juice increases leukocyte counts in a dose-dependent manner. Experiments were performed with the following treatment groups (eight mice/group): saline, healthy control mice administered saline; pure noni, animals administered pure juice from M. citrifolia fruit; noni 1:10, mice administered a 1:10 dilution of juice; noni 1:100, mice administered a 1:100 dilution of juice. Noni juice was administered orally in a volume of 100 µl per mouse for nine consecutive days. Body weight variations (a) were recorded during the noni juice regimen, and total leukocytes (b), lymphocytes (c) neutrophils (d) and monocytes (e) were recorded on the day of euthanasia. *p < .05.
Table 1. Liver function – biochemical plasma profiles of mice treated with saline or noni juice.
Table 2. Kidney function – biochemical plasma profiles of mice treated with saline or noni juice.
Figure 3. Noni juice modulates cytokine levels in the liver. Experiments were performed with the following treatment groups (eight mice/group): saline, healthy control mice administered saline; pure noni, animals administered pure juice from M. citrifolia fruit; noni 1:10, mice administered a 1:10 dilution of juice; noni 1:100, mice administered a 1:100 dilution of juice. Noni fruit juice was administered orally in a volume of 100 µl per mouse for nine consecutive days. Liver segments were collected, processed and analyzed at the conclusion of the 9-day treatment. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of the following cytokines in the tissue homogenates: (a) IFN-γ, (b) TNF-α, (c) IL-12, (d) IL-4, (e) IL-17, (f) IL-23 and (g) IL-10. The results are expressed as nanograms of cytokine per milliliter of homogenate supernatant and normalized by tissue weight. *p < .05.
Figure 4. Cytokine modulation in kidney was not as prominent as in other organs. Experiments were performed with the following treatment groups (eight mice/group): saline, healthy control mice administered saline; pure noni, animals administered pure juice from M. citrifolia fruit; noni 1:10, mice administered a 1:10 dilution of juice; noni 1:100, mice administered a 1:100 dilution of juice. Noni fruit juice was administered orally in a volume of 100 µl per mouse for nine consecutive days. Kidney samples were collected, processed and analyzed at the conclusion of the 9-day treatment. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of the following cytokines in the tissue homogenates: (a) IFN-γ, (b) TNF-α, (c) IL-12, (d) IL-4, (e) IL-17, (f) IL-23 and (g) IL-10. The results are expressed as nanograms of cytokine per milliliter of homogenate supernatant and normalized by tissue weight. *p < .05.
