A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

Figures & data

Table 1. Change from baseline of skin moisture measurements following single application of NTP-CE (first 24 h) and after twice-daily topical application over 4 weeks (day 29).

–	A	B	p Values^a
Baseline	33.61 ± 5.07	32.90 ± 4.63	–
2 h	0.43 ± 3.23	21.88 ± 7.31	<.001
4 h	0.76 ± 2.79	22.23 ± 5.96	<.001
8 h	−0.48 ± 2.93	18.34 ± 6.69	<.001
24 h	−1.72 ± 3.62	3.76 ± 3.49	<.001
AUC0 − 24h	−15.90 ± 49.03	302.03 ± 97.32	<.001
Day 29^b	−2.46 ± 4.93	5.58 ± 7.36	<.001

N = 44. Data are given in i.u. All values are presented as mean ± SD.

A: untreated area; B: treated with NTP-CE; Baseline: baseline corneometry value before product application; 2 h/4 h/8 h/24 h: change from baseline by hours after product application; AUC_0–24 h: area under the curve from baseline over 24 h after single application of NTP-CE; h: hour; Day 29: change from baseline after 4 weeks of application.

^a For mean change from baseline (B vs. A), paired t-test.

^b Measurement took place approximately 12–16 h after last NTP-CE application.

Note: An increase in skin capacitance reflects a skin-moisturizing effect.

Table 2. Results of Raman spectroscopy assessments related to SC at baseline and change from baseline following single application of NTP-CE.

					p Values^a
Parameter	–	Baseline	4 h	8 h	at 4 h	at 8 h
AUC (Part 1) [g/cm^2]	A	196.15 ± 35.76	−13.39 ± 20.81	−20.78 ± 29.32	.013	.537
	B	183.60 ± 17.12	−45.10 ± 30.46	−28.19 ± 29.73	–	–
AUC (Part 2) [g/cm^2]	A	283.21 ± 40.26	−20.05 ± 29.45	−28.87 ± 41.63	.981	.230
	B	263.49 ± 23.34	−20.35 ± 44.75	−8.26 ± 56.16	–	–
AUC (Part 3) [g/cm^2]	A	367.95 ± 46.65	−26.80 ± 41.37	−37.03 ± 55.61	.086	.061
	B	340.94 ± 30.41	3.82 ± 61.97	11.44 ± 87.08	–	–
Water gradient [g/cm^4]	A	2.09 ± 0.33	0.11 ± 0.19	0.14 ± 0.21	.036	.249
	B	2.22 ± 0.18	0.51 ± 0.41	0.31 ± 0.37	–	–
Thickness [μm]	A	19.57 ± 2.41	−1.31 ± 1.77	−1.64 ± 2.59	.057	.059
	B	18.04 ± 1.54	0.64 ± 3.18	0.94 ± 4.68	–	–

N = 10. All values are presented as mean ± SD.

A: untreated area; B: treated with NTP-CE; Part 1: upper SC compartment; Part 2: intermediate SC compartment; Part 3: deep SC compartment; Baseline: baseline value before product application; 4 h/8 h: change from baseline by hours after product application.

^a For change from baseline (B vs. A), paired t-test.

Table 3. Change from baseline in cutaneous scores for dryness and roughness during twice-daily topical application of NTP-CE over 4 weeks in infants.

Dryness	Body	Face
Baseline (N = 57)	0.4 ± 0.1	0.4 ± 0.1
Day 7 (N = 56)	−0.3 ± 0.1 [−65%]	−0.2 ± 0.1 [−56%]
Day 14 (N = 55)	−0.4 ± 0.1 [−87%]	−0.3 ± 0.1 [−76%]
Day 28 (N = 52)	−0.4 ± 0.1 [−88%]	−0.1 ± 0.1 [−38%]
Roughness	Body	Face
Baseline (N = 57)	0.2 ± 0.1	0.2 ± 0.1
Day 7 (N = 56)	−0.2 ± 0.1 [−92%]	−0.1 ± 0.1 [−59%]
Day 14 (N = 55)	−0.2 ± 0.1 [−93%]	−0.2 ± 0.1 [−76%]
Day 28 (N = 52)	−0.1 ± 0.1 [−44%]	0.0 ± 0.1 [9%]

Values are presented as mean ± SEM [% change from baseline].

Baseline: baseline value before product application; Day 7/Day 14/Day 28: change from baseline by days after initiation of product application.

Note: Worst possible rating = 4. A decrease in scores reflects improved condition.

Table 4. Change from baseline in skin capacitance during twice-daily topical application of NTP-CE over 4 weeks in infants with dry skin.

–	Corneometry result	p Values^a
Baseline (N = 21)	28.38 ± 4.25	–
Day 7 (N = 20)	12.15 ± 9.39	<.001
Day 14 (N = 21)	15.24 ± 8.84	<.001
Day 28 (N = 17)	14.00 ± 7.43	<.001

Data are given in i.u. All values are presented as mean ± SD.

Baseline: baseline corneometry value before product application; Day 7/Day 14/Day 28: change from baseline by days after initiation of product application.

^a For mean change from baseline, paired t-test.

Note: The observed increases in skin capacitance reflect a skin-moisturizing effect.