Preoperative and postoperative evaluation of survivin in peripheral blood of patients with non-melanoma skin cancers. A pilot study

Figures & data

Table 1. Demographics and Laboratory results of patients.

						CRP		Survivin
	ID	Group	Gender	Age		Pre- surgery	Post- surgery	Pre- surgery	Post- surgery
1	501	BCC	M	84		1.01	2.06	10.2	7.6
2	502	BCC	M	74		1.75	0.8	13.9	14.2
3	503	BCC	M	64		0.3	0.23	24.8	23
4	504	BCC	M	73		1.1	0.66	20.15	24.5
5	505	BCC	F	59		3.7	3.72	9.95	15.9
6	506	BCC	F	80		4.9	2.5	257.8	379.7
7	507	BCC	F	74		9.2	15.1	10.4	14.37
8	508	BCC	M	68		3.39	2.41	10.2	8.1
9	509	BCC	M	59		2.41	1.74	9.8	9.6
10	510	BCC	M	72		2.93	3.86	9.5	9.1
11	601	SCC	M	86		3	2.37	8.7	8.5
12	602	SCC	M	88		0.5	0.28	8.4	10.3
13	603	SCC	M	70		5.4	0.75	24.4	12.3
14	604	SCC	F	88		5.12	1.75	152.3	242.8
15	605	SCC	M	80		0.8	0.15	24.4	8.2
16	606	SCC	M	82		0.8	1.33	10.8	14.3
17	607	SCC	M	86		11.9	2.83	48.9	10.5
18	608	SCC	M	72		2.38	1.55	17.6	13.2
19	609	SCC	F	82		0.24	2.05	31.4	28.3
20	610	SCC	M	84		0.54	3.13	31.1	26.5

Table 2. Survivin descriptive statistics for basal cell carcinoma (BCC) group, squamous cell carcinoma (SCC) group and both groups combined.

Survivin descriptive statistics
	N	Mean	Std. deviation	Minimum	Maximum	Median	Asymp. Sig. (2-tailed)
BCC – survivin pre	10	37.67	77.52	9.50	257.80	10.30	0.38627
BCC – survivin post	10	50.61	115.78	7.60	379.70	14.29
SCC – survivin pre	10	35.80	42.80	8.40	152.30	24.40	0.24112
SCC – survivin post	10	37.49	72.48	8.20	242.80	12.75
Both groups – survivin pre	20	36.74	60.95	8.40	257.80	15.75	0.73685
Both groups – survivin post	20	44.05	94.25	7.60	379.70	13.70

Survivin pre: survivin levels before operation; survivin post: survivin levels after operation; Asymp. Sig. (2-tailed): Asymptotic Significance 2-tailed; Std. deviation: Standard deviation.

Wilcoxon test with survivin pre and survivin post as variables.

Table 3. C-reactive protein (CRP) descriptive statistics for basal cell carcinoma (BCC) group, squamous cell carcinoma (SCC) group and both groups combined.

CRP descriptive statistics
	N	Mean	Std. deviation	Minimum	Maximum	Median	Asymp. Sig. (2-tailed)
BCC – CRP pre	10	3.069	2.569	0.30	9.20	2.67	0.72128
BCC - CRP post	10	3.308	4.317	0.23	15.10	2.24
SCC - CRP pre	10	3.068	3.642	0.24	11.90	1.59	0.20262
SCC - CRP post	10	1.619	1.017	0.15	3.13	1.65
Both groups - CRP pre	20	3.068	3.067	0.24	11.90	2.40	0.31346
Both groups - CRP post	20	2.463	3.173	0.15	15.10	1.90

CRP pre: CRP levels before operation; CRP post: CRP levels after operation.

Wilcoxon test with CRP pre and CRP post as variables.

Table 4. C-reactive protein (CRP) paired differences for basal cell carcinoma (BCC) group, squamous cell carcinoma (SCC) group and both groups combined.

Paired differences
		Std.	Std. error	95% Confidence interval of the difference				Sig.
	Mean	deviation	mean	Lower	Upper	t	df	(2-tailed)
BCC pair 1: CRP pre log – CRP post log	0.06123	0.21717	0.06867	−0.09412	0.21658	0.892	9	0.396
SCC pair 1: CRP pre log – CRP post log	0.12993	0.60632	0.19174	−0.30381	0.56367	0.678	9	0.515
Both groups Pair 1: CRP pre log – CRP post log	0.09558	0.44466	0.09943	−0.11253	0.30369	0.961	19	0.348

CRP pre-log: CRP levels before operation, transformed to fit normal distribution; CRP post-log: CRP levels after operation, transformed to fit normal distribution. Paired samples T-test with CRP pre-log and CRP post-log as variables; df: degrees of freedom.

Table 5. Association between group and age.

Directional measures
			Value
Nominal by interval	Eta	Age dependent	0.623
		Group dependent	0.837

Table 6. Association between group and gender.

Directional measures
			Value	Asymptotic standard error	Approximate T	Approximate significance
Nominal by interval	Lambda	Symmetric	0.067	0.250	0.259	0.796
		Gender Dependent	0.000	0.000	.^C	.^C
		Group Dependent	1.00	0.367	0.259	0.796

Figure 1. The Age difference between the two Groups as depicted in the form of a boxplot. Note: Case #13 appears to be a possible outlier in the SCC Group. BCC: basal cell carcinoma, SCC: squamous cell carcinoma.

Data availability statement

The data that support the findings of this study are available from the corresponding author, ET, upon reasonable request.