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Research Article

A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study

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Article: 2216323 | Received 07 Dec 2022, Accepted 16 May 2023, Published online: 14 Aug 2023

Figures & data

Figure 1. Study treatments and assessments.

Figure 1. Study treatments and assessments.

Figure 2. Study organogram with all time points.

Figure 2. Study organogram with all time points.

Table 1. Demographics and baseline characteristics (ITT population).

Figure 3. Evolution of Crow’s feet and wrinkles (a) Crow’s feet volume; (b) Crow’s feet depth; (c) Clinical score of neck wrinkles; (d) clinical score of décolleté wrinkles.

Figure 3. Evolution of Crow’s feet and wrinkles (a) Crow’s feet volume; (b) Crow’s feet depth; (c) Clinical score of neck wrinkles; (d) clinical score of décolleté wrinkles.

Table 2. Summary of clinical radiance scores, skin hydration, elasticity, dermal density, and pore size.

Figure 4. Skin density assessed on the crow’s feet and the cheeks using high-frequency ultrasound imaging.

Figure 4. Skin density assessed on the crow’s feet and the cheeks using high-frequency ultrasound imaging.

Figure 5. Changes in physicians’ and subjects’ GAIS compared with baseline in the face.

Figure 5. Changes in physicians’ and subjects’ GAIS compared with baseline in the face.

Table 3. Subjects’ impressions of injection procedure and efficacy.

Figure 6. Changes in Rosenberg self-esteem scale. NS: not significant.

Figure 6. Changes in Rosenberg self-esteem scale. NS: not significant.

Table 4. Summary of adverse events.

Data availability statement

There is no associated data available.