Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient

Figures & data

Figure 1. (a) Erythemas and red papules could be seen on the cheeks, Chin, trunk and extremities including flexural distribution. The skin on the entire body was dry. (b) Signs on slit-lamp examination when the patient had ophthalmologic symptoms were consistent with uveitis. (c) No evident signs were found on slit-lamp examination after management.

Figure 2. Eosinophil count and total IgE level changes during dupilumab therapy.

Table 1. Clinical characteristics of dupilumab-related uveitis previously reported.

Author (year)	Case No.	Course of dupilumab therapy before uveitis onset	Ophthalmic symptoms	Primary ophthalmic examination findings	Type of uveitis	Unilateral or bilateral uveitis
Ayasse et al. (2021)	NA	>1 year	Redness, pain, worsened visual acuity	Chamber inflammatory cells, posterior synechiae of the iris, thickening of the choroid, serous retinal detachments	Pan uveitis	Bilateral
Padidam et al. (2022)	Case 1	>1 year	Pain, photophobia, worsened visual acuity	Anterior chamber cell, posterior synechiae, anterior vitreous cells, submacular fluid, optic nerve head edema, choroidal folds	Pan uveitis	Bilateral
	Case 2	2 years	Blurry vision	Anterior chamber cell, vitreous cell, CME, subretinal fluid	Anterior and intermediate uveitis	Bilateral
	Case 3	18 months	Not reported	Anterior chamber cellular reaction, pigmented chorioretinal scars	Relentless placoid chorioretinitis	Bilateral
	Case 4	7 months	Blurred vision	CME, retinal vascular leakage within and outside macula	Posterior uveitis	Bilateral

CME: cystoid macular edema; NA: not applicable.

Data availability statement

The data that support the findings of this study are available from the corresponding author, TW, upon reasonable request.