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Review Article

Systematic review of mesotherapy: a novel avenue for the treatment of hair loss

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, & ORCID Icon
Article: 2245084 | Received 06 Jul 2023, Accepted 01 Aug 2023, Published online: 09 Aug 2023

Figures & data

Figure 1. Flow diagram of the systematic search.

Figure 1. Flow diagram of the systematic search.

Figure 2. Global reports of studies on mesotherapy for hair loss. The greatest number of studies on mesotherapy so far have been reported from Egypt, followed by India, Spain, and Brazil. A total of 10 clinical trials were identified, in addition to observational studies, case series, and reports. Image created with MapChart.

Figure 2. Global reports of studies on mesotherapy for hair loss. The greatest number of studies on mesotherapy so far have been reported from Egypt, followed by India, Spain, and Brazil. A total of 10 clinical trials were identified, in addition to observational studies, case series, and reports. Image created with MapChart.

Table 1. Summary of randomized controlled trials on mesotherapy for hair loss.

Table 2. Summary of non-randomized controlled trials, studies, and reports on mesotherapy in patients with pattern hair loss.

Table 3. Summary of studies and reports on adverse effects associated with mesotherapy.

Figure 3. Summary of Interventions, regimens, and the Efficacies of agents used for mesotherapy to treat hair loss. Data from 26 of the 28 studies that reported the number and frequency of sessions for each intervention have been summarized. Here, “+++” refers to statistically significant improvement in trichoscopic parameters (total or terminal hair count, total or terminal hair density, hair diameter, vellus hair count or density) or hair regrowth percentage, “++” refers to statistically significant improvement in global photographic/physician assessment or patient self-assessment, “+” refers to improvement in any of the parameters without statistical significance, “–” refers to no improvement in any of the parameters, and “– –” refers to adverse effects observed in response to mesotherapy.

Figure 3. Summary of Interventions, regimens, and the Efficacies of agents used for mesotherapy to treat hair loss. Data from 26 of the 28 studies that reported the number and frequency of sessions for each intervention have been summarized. Here, “+++” refers to statistically significant improvement in trichoscopic parameters (total or terminal hair count, total or terminal hair density, hair diameter, vellus hair count or density) or hair regrowth percentage, “++” refers to statistically significant improvement in global photographic/physician assessment or patient self-assessment, “+” refers to improvement in any of the parameters without statistical significance, “–” refers to no improvement in any of the parameters, and “– –” refers to adverse effects observed in response to mesotherapy.

Data availability Statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study.