Comparison of the efficacy of tacrolimus 0.1% ointment vs calcipotriol/betamethasone in combination with NBUVB in treatment of vitiligo

Figures & data

Table 1. demographic and clinical characteristics of the participants.

	Treatment
	Calcipotriol/betamethasone		Tacrolimus 0.1% ointment
	cream
Variable	N	Percent	N	Percent	Sig
Gender					0.437
Male	9	45	12	57
Female	11	55	9	43
Age					0.146
≤ 33 years	14	70	10	48
More than 33 years	6	30	11	52
Time since diagnosis					0.278
≤ 4 years	9	45	13	62
More than 4 years	11	55	8	38
Number of visits					0.265
1st	12	60	16	76
Follow up	8	40	5	24
Vit. B12					0.184
Low	4	20	1	4.8
Normal	16	80	20	95.2
Vit. D					1
Insufficient or low	17	85	18	86
Normal	3	15	3	14
Skin type					0.563
III	7	47	7	37
IV	8	53	12	63

Table 2. Efficacy of each treatment and the differences in the efficacy of both treatment groups at three and six months from baseline.

	Calcipotriol/betamethasone	Tacrolimus 0.1%	Sig
Mean of overall improvement percentage after 3 months	35.4	32.2	0.625
Mean of overall improvement percentage after 6 months	54.7	45.6	0.251
Sig.	0.001	0.011

Table 3. Repigmentation percentage in the treatment groups after 6 months from baseline.

	Excellent (76–100%)	Moderate (51–75%)	Mild (26–50%)	Minimal (1–25%)
Calcipotriol/betamethasone	15%	45%	30%	10%
Tacrolimus 0.1%	19%	10%	43%	28%

Figure 1. The repigmentation in the trunk (breast) of a female patient after 3 months and 6 months of treatment with calcipotriol/betamethasone cream (combined with VBUVB).

Figure 2. The repigmentation in the LL and foot of a male patient after 3 months and 6 months of treatment with tacrolimus 0.1% ointment (combined with VBUVB).

Table 4. Percentage of patients who showed excellent response to treatments in different body sites.

	Treatment groups
	Calcipotriol/betamethasone cream		Tacrolimus 0.1% ointment
	After 3 months	After 6 months	After 3 months	After 6 months
Face	2 (28.6%)	5 (71.4%)	5 (50%)	8 (80%)
Trunk	3 (20%)	6 (40%)	3 (30%)	5 (50%)
Upper limb	0	4 (26.7%)	1 (9.1%)	3 (37.3%)
Lower limb	0	3 (18.3%)	2 (14.3%)	3 (21.4)
Hands and feet	2 (13.3%)	2 (13.3%)	0	1 (5.9%)

Figure 3. Correlation of duration since diagnosis with repigmentation percentage after 3 months for the D group.

Figure 4. Correlation of duration since diagnosis with repigmentation percentage after 6 months for the D group.

Data availability statement

The data that support the findings of this study are not openly available due to reasons of sensitivity and are available from the corresponding author upon request.