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Case Report

Paradoxical tralokinumab-induced psoriasis in a patient with atopic dermatitis

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Article: 2258240 | Received 17 Jul 2023, Accepted 08 Sep 2023, Published online: 13 Sep 2023

Figures & data

Figure 1. Clinical presentation of severe AD prior to the initiation of systemic therapy with erythematous, dry skin and scratch marks on the back (A) and neck (B). the SCORAD (SCORing atopic dermatitis) was 65.

Figure 1. Clinical presentation of severe AD prior to the initiation of systemic therapy with erythematous, dry skin and scratch marks on the back (A) and neck (B). the SCORAD (SCORing atopic dermatitis) was 65.

Figure 2. Clinical presentation of paradoxical tralokinumab-induced psoriasis with red, scaly plaques on the elbows (A) and erythematous patches at the hairline covered by silvery-white scales (B).

Figure 2. Clinical presentation of paradoxical tralokinumab-induced psoriasis with red, scaly plaques on the elbows (A) and erythematous patches at the hairline covered by silvery-white scales (B).

Figure 3. Histology of a skin biopsy from the lesion on the elbow with hyper- and parakeratosis, acanthosis, papillomatosis and subcorneal Munro’s microabscess, that is typical for psoriasis. Hematoxylin-eosin staining, ×100.

Figure 3. Histology of a skin biopsy from the lesion on the elbow with hyper- and parakeratosis, acanthosis, papillomatosis and subcorneal Munro’s microabscess, that is typical for psoriasis. Hematoxylin-eosin staining, ×100.