Modalities of treatment for Nevus depigmentosus: review of the literature

Figures & data

Figure 1. Diagram of the included studies.

Table 1. Characteristics of ND treatment modality studies.

Treatment used	Type of the study	No. of patient	Treatment details	Additional therapy	Response	Recurrence of hypopigmentation	Reference
Surgical interventions	Case series	6	Non-cultured melanocyte-keratinocyte transplantation	Excimer laser	1 patient lost follow up 2 patients responded poorly 3 patients responded with repigmentation ranging from 80% to 100%	Yes, in 1 patient	Article 1
	Retrospective study	Total of patient is 25 patients: 3 were ND and 22 were vitiligo	Non-cultured melanocyte keratinocyte transplantation	–	VASI scores improvement: - short-term (62.5%±17.6%) -long term (83.3%±14.4%)	NA	Article 2
	Prospective study	Total of patient is 25 patients: 1 were ND and 24 were different depigmentary diseases	Non-cultured melanocyte keratinocyte transplantation	–	Poor response	NA	Article 3
	Retrospective study	Total of patient is 87 patients: 1 were ND and 86 were different depigmentary diseases	Non-cultured melanocyte keratinocyte transplantation	–	The lesion showed 78% repigmentation	NA	Article 4
	Case report	1	Cultured melanocyte keratinocyte transplantation	–	Excellent	No recurrence after 16 months	Article 5
	Prospective study	Total of patient is 12 patients: 1 were ND and 11 were vitiligo	Non-cultured melanocyte keratinocyte transplantation injected in donor area blister created by liquid nitrogen	Solar UVA	80(1)% repigmentation	NA	Article 6
	Case report	1	Tissue graft harvested using suction blister	Oral 4,5,8-trimethylpsoralen	Good repigmentation limited to the grafted area, there was no repigmentation in the intergraft areas	NA	Article 7
	Case report	1	Tissue graft harvested using suction blister	Topical PUVASOL (Psoralen plus UltraViolet-A of SOLar origin)	Satisfactory repigmentation	No recurrence after 10 years	Article 8
	Case Report	1	Suction blister grafting	–	Satisfactory repigmentation	NA	Article 9
	Case Report	1	Suction blister grafting	–	Satisfactory repigmentation	NA	Article 10
	Case Report	1	Suction blister grafting	–	Satisfactory repigmentation	There was a loss of pigmentation after 8 years	Article 20
Phototherapy	Case Report	1	Narrow-band UVB	–	Significant repigmentation.	NA	Article 11
	Case Report	1	Excimer laser	–	Evident repigmentation clinically and by skin RCM	No recurrence after 1 month	Article 13
	Retrospective study	14	Excimer laser	–	71.4% of patient showed complete pigmentation	Of 6 patients followed up, 4 (66.7%) showed loss of pigmentation at the treatment site 3 to 6 months later, and 1 (16.7%) showed no recurrence of ND 1 year after treatment.	Article 14
	Case Report	1	Excimer laser	–	Complete clearence	NA	Article 15
Other Therapies	Case Report	1	Topical and oral steroid	–	No repigmentation	NA	Article 16