Reducing fracture incidence in children with osteogenesis imperfecta: contribution of orthotics to bisphosphonates treatment

Figures & data

Figure 1. (a–d). Histograms of the predictors and the outcome variables in the model. (a) Number of uses of orthoses; (b) Number of uses of bisphosphonates; (c) Number of positive changes; (d) Number of negative changes.

Histograms showing model predictors and outcome variables.

Table 1. Descriptive statistics of the predictors and the outcome variables in the model (n = 48).

Predictors	Mean (SD)	Median (IQR)	Range (Min-Max)
No. of uses of bracing	3.46 (4.03)	1.5 (0–7)	0-15
No. of uses of bisphosphonates	11.17 (7.31)	9.5 (5.0–16.75)	1-34
Outcome variables
No. of positive changes	1.90 (1.61)	1 (1–3)	0-7
No. of negative changes	0.75 (0.81)	1 (0–1)	0-3

No.:number; SD:standard deviation; IQR:Interquartile range; Min:minimum; Max:maximum.

Figure 2. (a–b). (a) Association between total use of bisphosphonates and total number of positive changes for patients whose total number of orthotic use was the median or lower. (b) Association between total use of bisphosphonates and total number of positive changes for patients whose total number of orthotic use was above the median. Note: The fit line shown in both graphs is the locally weighted scatterplot smoothing (LOWESS) line.

Graphs showing associations between the total use of bisphosphonates and the total number of positive or negative changes.

Table 2. Regression model for prediction of the total number of positive changes.

Variables in the model	B	SE	Wald	df	p-value	OR	95% CI for OR
Age	0.01	0.02	0.38	1	0.54	1.01	0.97–1.06
No. of bracing use	−0.02	0.05	0.22	1	0.64	0.98	0.88–1.08
No. of bisphosphonates use	0.00	0.03	0.00	1	0.96	1.00	0.95–1.05
Bracing × bisphosphonates	0.01	0.00	2.74	1	0.10	1.01	1.00-1.01

No.: Number; B: regression coefficient; SE: standard error; df: degrees of freedom; OR: odds ratio; CI: confidence interval.

Table 3. Regression model for prediction of the total number of negative changes.

Variables in the model	B	SE	Wald	df	p-value	OR	95% CI for OR
Age	–0.03	0.04	0.66	1	0.42	0.97	0.91–1.04
No. of bracing use	0.02	0.09	0.07	1	0.80	1.02	0.86–1.21
No. of bisphosphonates use	0.05	0.04	1.57	1	0.21	1.05	0.97–1.13
Bracing × Bisphosphonates	0.00	0.00	0.01	1	0.94	1.00	0.99–1.01

B: regression coefficient; SE: standard error; Wald: Wald test to assess constraints on statistical parameters; df: degrees of freedom; OR: odds ratio; CI: confidence interval.