Figures & data
Table I. Key studies examining HPA axis activity in the context of further clinical variables to distinguish subgroups within major depression.
Table II. Key studies examining sleep-EEG changes in the context of further clinical variables to distinguish subgroups within major depression.
Table III. Key studies examining HPA axis activity and sleep-EEG changes in the context of further clinical variables to distinguish subgroups within major depression.
Wong ML, Kling MA, Munson PJ, Listwak S, Licinio J, Prolo P, Karp B, McCutcheon IE, et al. Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone. Proc Natl Acad Sci USA 2000; 97: 325–330 Gold PW, Wong ML, Goldstein DS, Gold HK, Ronsaville DS, Esler M, Alesci S, Masood A, et al. Cardiac implications of increased arterial entry and reversible 24 h central and peripheral norepinephrine levels in melancholia. Proc Natl Acad Sci USA 2005; 102: 8303–8308 Carroll BJ, Cassidy F, Naftolowitz D, Tatham NE, Wilson WH, Iranmesh A, Liu PY, Veldhuis JD. Pathophysiology of hypercortisolism in depression. Acta Psychiatr Scand 2007; 115: 90–103 Kunzel HE, Binder EB, Nickel T, Ising M, Fuchs B, Majer M, Pfennig A, Ernst G, et al. Pharmacological and nonpharmacological factors influencing hypothalamic–pituitary–adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex–CRH test. Neuropsychopharmacology 2003; 28: 2169–2178 Coryell W, Young E, Carroll B. Hyperactivity of the hypothalamic–pituitary–adrenal axis and mortality in major depressive disorder. Psychiatry Res 2006; 142: 99–104 Kaestner F, Hettich M, Peters M, Sibrowski W, Hetzel G, Ponath G, Arolt V, Cassens U, et al. Different activation patterns of proinflammatory cytokines in melancholic and non-melancholic major depression are associated with HPA axis activity. J Affect Disord 2005; 87: 305–311 Kupfer DJ, Targ E, Stack J. Electroencephalographic sleep in unipolar depressive subtypes: Support for a biological and familial classification. J Nerv Ment Dis 1982; 170: 494–498 Kupfer DJ, Reynolds CF, III, Grochocinski VJ, Ulrich RF, McEachran A. Aspects of short REM latency in affective states: A revisit. Psychiatry Res 1986; 17: 49–59 Thase ME, Kupfer DJ, Ulrich RF. Electroencephalographic sleep in psychotic depression. A valid subtype?. Arch Gen Psychiatry 1986; 43: 886–893 Armitage R, Emslie GJ, Hoffmann RF, Rintelmann J, Rush AJ. Delta sleep EEG in depressed adolescent females and healthy controls. J Affect Disord 2001; 63: 139–148 Stefos G, Staner L, Kerkhofs M, Hubain P, Mendlewicz J, Linkowski P. Shortened REM latency as a psychobiological marker for psychotic depression? An age-, gender-, and polarity-controlled study. Biol Psychiatry 1998; 44: 1314–1320 Hatzinger M, Hemmeter UM, Baumann K, Brand S, Holsboer-Trachsler E. The combined DEX–CRH test in treatment course and long-term outcome of major depression. J Psychiatr Res 2002; 36: 287–297 Hatzinger M, Hemmeter UM, Brand S, Ising M, Holsboer-Trachsler E. Electroencephalographic sleep profiles in treatment course and long-term outcome of major depression: Association with DEX/CRH-test response. J Psychiatr Res 2004; 38: 453–465 Antonijevic IA, Murck H, Frieboes RM, Uhr M, Steiger A. On the role of menopause for sleep-endocrine alterations associated with major depression. Psychoneuroendocrinology 2003; 28: 401–418 Krieg JC, Berger M. REM sleep and cortisol response to the cholinergic challenge with RS 86 in normals and depressives. Acta Psychiatr Scand 1987; 76: 600–602