Designing and Testing of an Effective Oil-in-Water Microemulsion Drug Delivery System for In Vivo Application

Figures & data

FIG. 1. Molecular structure of quercetin.

FIG. 2. Ternary phase diagram of clove oil/Tween 20/water system.

FIG. 3. Effect of additives on the phase diagrams of clove oil/ Tween 20/water system at 6 different compositions 82/12/7 (A), 47/38/15 (B), 33/46/21 (C), 25/46/29 (D), 15/40/45 (E), and 5/30/65(F), as designated in text.

FIG. 4. Percentage of particle size distribution versus diametera (nm) obtained from DLS measurement for the microemulsion composition 5/30/65 (F).

TABLE 1 Effect of quercetin on 30-day infected hamster models undergoing experimental leishmaniasis

Group	Parasite load in the spleen × 10^− 8	Percent suppression of spleen parasite load
Infected control	11.1 ± 0.50	—
Free-drug treated	7.73 ± 0.23	30
Microemulsion-incorporated drug treated	5.57 ± 0.41	50
Placebo microemulsion treated	9.86 ± 0.49	11

Values are expressed as mean ± SD (n = 4).