Figures & data
TABLE 1 Fatty acids and analogs studied as a skin permeation enhancer
FIG. 1 Effect of carbon-chain length of saturated fatty acids on the transdermal permeation of diclofenac through rat skin. Each point represents the mean ± S.D. of four experiments.
FIG. 2 Effect of carbon-chain length of cis-monounsaturated fatty acids on the transdermal permeation of diclofenac through rat skin. Each point represents the mean ± S.D. of four experiments.
FIG. 3 Effect of number of double bonds in octadecanoic acids on the transdermal permeation of diclofenac through rat skin. Each point represents the mean ± S.D. of four experiments.
FIG. 4 Effect of various fatty acids (1.0%, w/v) on the rat skin permeation rate of diclofenac, saturated in propylene glycol at 37°C. Each point represents the mean ± S.D. of four experiments.
TABLE 2 In vitro rat skin permeation parameters of diclofenac, saturated in propylene glycol containing 1% (w/v) of fatty acids at 37°C
FIG. 5 Effect of functional group of oleic acid analogs on the transdermal permeation of diclofenac through rat skin; (•) no enhancer, (▴) oleic acid, (▾ oleamide, (▪ oleyl alcohol. Each point represents the mean ± S.D. of four experiments.
TABLE 3 In vitro rat skin permeation parameters of diclofenac, saturated in propylene glycol containing 1% (w/v) of oleic acid analogs at 37°C