One-Year Observation of Wistar Rats after Intravenous Infusion of Hemoglobin-Vesicles (Artificial Oxygen Carriers)

Figures & data

Figure 1 Changes in body weight of the Wistar rats during one year following intravenous bolus infusion of HbV at a dose rate of 20 ml/kg. All the rats were housed individually in cages and provided with food and water ad libitum.

Figure 2 Changes in plasma biochemical parameters after intravenous bolus infusion of HbV into Wistar rats at a dose rate of 20 ml/kg. Data for 7 days (white bars) are cited from our previous report [[8]]. B, baseline.

Figure 3 Changes in plasma levels of lipid components, iron, and bilirubin after intravenous bolus infusion of HbV into Wistar rats at a dose rate of 20 ml/kg. Data for 7 days (white bars) are cited from our previous report [[8]]. B, baseline. The values of black bars are from one-year-old rats housed in pairs in cages, not individually (cited from the breeder's data) [[17]].

Figure 4 Histology of lung one year after bolus infusion of HbV stained with hematoxylin/eosin. Scale bar, 100 µm.

Sakai, H., Horinouchi, H., Masada, Y., Takeoka, S., Kobayashi, K., Tsuchida, E. (2004). Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model. Biomaterials 25: 4371–4325.

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