Genetic variant of CCND1: Association with HPV-mediated cervical cancer in Indian population

Abstract

The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) of CCND1 with susceptibility to cervical cancer was investigated. The study included 200 cervical cancer cases along with an equal number of healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk for the development of cervical cancer (odds ratio (OR) 2.49; 95% confidence interval (CI) 1.51–4.09; p = 0.0004) compared with GG+GA genotypes. For the 1722 locus, the frequency of the polymorphic ‘C’ allele was strongly associated with a reduced risk of cervical cancer (p = 0.019; OR 0.71; 95% CI 0.54–0.94). Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. And G1722C polymorphism may play a protective role against the development of human papillomavirus-associated cervical cancer among Indian women.

Keywords::

• Cyclin D1
• cervical cancer
• human papillomavirus
• single nucleotide polymorphism
• G870A
• G1722C

Acknowledgements

The authors thank patients and their relatives for their support and cooperation. The study was supported by core funds of ICPO (ICMR), Noida.

Declaration of interest: We report no potential conflicts of interest. I hereby declare on behalf of all authors that the work has not been published and is not being considered for publication elsewhere.