Differences in male climacteric symptoms with aging among rotating night shift workers

Figures & data

Table 1. Baseline characteristics.

	Number	Proportion (％)
Age (years) (n = 1524)
20–29	451	29.7
30–39	237	15.6
40–49	382	25.1
50–59	337	22.1
≥60	93	6.1
missing	24	1.6
Duration of shiftwork (years) (n = 1500)
<10	570	38.0
11–19	270	18.0
20–29	319	21.3
30–39	198	13.2
≥40	129	8.6
missing	14	0.9
Types of shift (n = 1500)
three-shift work	1110	74.0
two-shift work	343	22.9
others	46	3.1
missing	1	0.1
Employment status (n = 1500)
regular employee	1301	86.7
contract employee	117	7.8
dispatched employee	31	2.1
part-time workers	7	0.5
others	31	2.1
missing	13	0.9

Table 2. Proportion of AMS symptoms according to age.

	Symptoms	Total (n = 1500)		20s (n = 451)		30s (n = 237)		40s (n = 382)		50s（n = 337)		60s (n = 93)
		n	(%)	n	(%)	n	(%)	n	(%)	n	(%)	n	(%)
1	Decline in your feeling of general well-being	761	50.7	171	37.9	118	49.8	211	55.2	208	61.7	53	57.0
2	Joint pain and muscular ache	797	53.1	133	29.5	123	51.9	228	59.7	251	74.5	62	66.7
3	Excessive sweating	256	17.1	61	13.5	38	16.0	74	19.4	69	20.5	14	15.1
4	Sleep problems	806	53.7	218	48.3	127	53.6	219	57.3	197	58.5	45	48.4
5	Increased need for sleep, often feeling tired	974	64.9	278	61.6	151	63.7	262	68.6	227	67.4	56	60.2
6	Irritability	824	54.9	235	52.1	140	59.1	228	59.7	183	54.3	38	40.9
7	Nervousness	603	40.2	167	37.0	97	40.9	167	43.7	144	42.7	28	30.1
8	Anxiety	457	30.5	130	28.8	69	29.1	125	32.7	113	33.5	20	21.5
9	Physical exhaustion / lacking vitality	891	59.4	185	41.0	133	56.1	268	70.2	241	71.5	64	68.8
10	Decrease in muscular strength	911	60.7	173	38.4	144	60.8	261	68.3	263	78.0	70	75.3
11	Depressive mood	661	44.1	175	38.8	105	44.3	180	47.1	161	47.8	40	43.0
12	Feeling that you have passed your peak	532	35.5	58	12.9	69	29.1	154	40.3	194	57.6	57	61.3
13	Feeling burnt out, having hit rock-bottom	315	21.0	62	13.7	41	17.3	98	25.7	91	27.0	23	24.7
14	Decrease in beard growth	178	11.9	14	3.1	22	9.3	62	16.2	64	19.0	16	17.2
15	Decrease in ability/frequency to perform sexually	536	35.7	49	10.9	69	29.1	161	42.1	200	59.3	57	61.3
16	Decrease in the number of morning erections	542	36.1	49	10.9	71	30.0	168	44.0	195	57.9	59	63.4
17	Decrease in sexual desire/libido	368	24.5	40	8.9	44	18.6	109	28.5	138	40.9	37	39.8

Figure 1. Total AMS scores according to age. The bottom line, middle line and top line of box-and-whisker plot indicate 25 percentile, median, and 75 percentile, respectively. Crosses show the mean values. *20s vs 40s or 50s or 60s (p < 0.001), **30s vs 50s (p = 0.001) 　***30s vs 60s (p = 0.035).

Table 3. Degrees of symptoms according to age.

Age (years)	Degree of symptoms（Total AMS scores)
	No symptoms (17–26)%	Mild (27–36) %	Moderate (37–49) %	Severe (50–85) %
20–29	69.5	20.1	8.6	1.7
30–39	58.0	26.9	11.9	3.2
40–49	46.7	27.8	19.5	5.9
50–59	37.2	30.9	25.7	6.3
60–69	39.7	39.7	15.1	5.5

Values indicate the proportions of subjects.

Table 4. Psychological symptoms, somatic symptoms and sexual symptoms in AMS according to age.

		20s	30s	40s	50s	60s	All subjects	Significance
Numbers		385	204	308	258	73	1228
All symptoms	Median	23	25	28	30	29	26	20s vs 40s or 50s or 60s (p < 0.001) 30s vs 50s (p = 0.001) 30s vs 60s (p = 0.035)
	25–75% tile	19–30	20–32.75	22–38	24–40	23.5–36	21–35
	Mean (±SD)	25.5(±8.9)	27.7 (±10.3)	30.9 (±11.2)	32.9 (±11.2)	30.7 (±9.6)	29.1 (±10.7)
Psychological symptoms （5 items）5–25 points	Median	7	7	7	7	6	7	ns
	25–75% tile	5–10	5–9.75	5–11	5–10	5–8.5	5–10
	Mean (±SD)	8.0 (±3.7)	8.1 (±3.7)	8.7 (±4.0)	8.5 (±3.7)	7.5 (±3.1)	8.3 ± 3.8
Somatic symptoms (7 items) 7–35 points	Median	10	11.5	14	14	13	12	20s vs 40s or 50s (p < 0.001), 20s vs 60s (p = 0.002), 30s vs 40s (p = 0.002), 30s vs 50s (p < 0.001)
	25–75% tile	8–14	9–15.75	10–17	11–18.25	10.5–16	9–17
	Mean (±SD)	11.8 (±4.7)	12.8 (±5.1)	14.3 (±5.2)	15 (±5.1)	13.6 (±4.5)	13.4 ± 5.1
Sexual symptoms （5 items）5–25 points	Median	5	5	7	9	9	6	20s vs 30s or 40s or 50s or 60s (p < 0.001), 30s vs 40s or 50s or 60s(p < 0.001), 40s vs 50s or 60s (p < 0.001)
	25%–75% tile	5–5	5–8	5–10	6–12	6–12	5–9
	Mean (±SD)	5.7 (±3.7)	6.9 (±3.7)	7.9 (±4.0)	9.4 (±3.7)	9.6 (±3.1)	7.5 ± 3.8

SD: standard deviation.