The efficacy and safety of tadalafil in the management of erectile dysfunction with diabetes and blood circulation issues

Figures & data

Figure 1. Scheme of the capillary loop measurements (×200). Apical limb width and Capillary width.

The capillaries on the fingernails are illustrated by a round column at the top, and the small one inside the large column also has a round column at the top. The figure displays the “width” of the column plot and “Apical” as the vertex at the top of each column.

Table 1. Characteristics of studies.

	(N = 20)
Age (years)	51.11 ± 9.01
Height (cm)	171.55 ± 4.45
Weight (kg)	80.75 ± 15.69
BMI (kg/m^2)	39.27 ± 15.46
Waist measure (cm)	96.3 ± 10.18
SBP (mmHg)	137.20 ± 14.09
DBP (mmHg)	84 ± 9.68
Pulse	82.75 ± 11.29

Mean ± SD.

BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure.

Table 2. Questionnaire.

	Pre	Post	p-value
IIEF-15	12.6 ± 4.41	19.8 ± 5.95	>.005****
IPSS	10.95 ± 7.36	8.4 ± 7.36	.01*
QoL	2.5 ± 1.1	2.15 ± 1.31	.12

Mean ± SD.

IIEF-15: International Index of Erectile Function; IPSS: International Prostate Symptom Score; QoL: Quality of life.

Table 3. Laboratory test.

		Pre	Post	p-value
Chemistry	HbA1C (%)	7.47 ± 1.30	7.37 ± 1.1	.5088
	Troponin (ng/mL)	0.01 ± 0.01	0.01 ± 0.01	.3446
	BUN (mg/dL)	14.3 ± 3.65	14.91 ± 4.48	.415
	Creatinine (mg/dL)	0.92 ± 0.19	0.89 ± 0.19	.1167
	FBS (mg/dL)	168.8 ± 49.33	182.35 ± 74.45	.2856
	AST (U/L)	30.35 ± 18.62	23.65 ± 8.86	.0376*
	ALT (U/L)	39.85 ± 33.54	29.1 ± 14.84	.2223
	γ-GTP (U/L)	43.55 ± 31.13	43.9 ± 30.42	.6432
	CRP (mg/dL)	0.08 ± 0.06	0.11 ± 0.19	.8498
CBC&Diff	WBC (10^3/µL)	6.45 ± 1.58	6.44 ± 1.38	.9856
	Hemoglobin (g/dL)	14.62 ± 2.41	15.23 ± 0.98	.9038
	Platelet (10^3/µL)	230.95 ± 51.15	228.4 ± 50.12	.5176
Lipid	Total Cholesterol (mg/dL)	154.3 ± 35.63	154.85 ± 34.93	.7086
	HDL-Cholesterol (mg/dL)	48.4 ± 9.87	49.3 ± 10.47	.5103
	LDL-Cholesterol (mg/dL)	91.3 ± 26.49	90.85 ± 28.89	.6273
	Triglyceride (mg/dL)	153.65 ± 127.80	158.45 ± 123.38	.75662
Urine	Micro albumin (mg/dL)	7.77 ± 18.73	7.26 ± 14.03	.6435
Capillary	Apical ($\mathrm{\mu }\mathrm{m}$)	13.1 ± 6.07	14.65 ± 6.81	.0433*
	Width (µm)	35.4 ± 7.63	37.55 ± 8.96	.2081
	Speed ($\mathrm{\mu }\mathrm{m}/\mathrm{s})$	81.5 ± 29.56	124.1 ± 149.45	.2123
	Flow ($\mathrm{\mu }\mathrm{m}$^3/s)	9035.5 ± 7433.99	11946.65 ± 11476.74	.0441*
Cancer maker	PSA (mg/dL)	1.15 ± 0.76	1.28 ± 0.80	.1787
Hormone	Testosterone (ng/dL)	482.2 ± 147.86	473.85 ± 168.16	.5135
Bone metabolism	25-OH vit D3 (ng/mL)	14.19 ± 5.74	12.39 ± 4.68	.07
EKG	HR (bpm)	73.2 ± 6.75	73.9 ± 11.88	.7309
	P-R	169.7 ± 12.9	172.5 ± 14.24	.1937
	QT	375.45 ± 20.96	385.15 ± 30.70	.1035

Biochemical parameters and EKG in study group pre and post taking Tadalafil 5 mg.

Mean ± SD. BUN: blood urea nitrogen; FBS: fasting blood sugar; AST: aspartate aminotransferase; ALT: alanine aminotransferase; γ-GTP (Gamma-GTP): gamma glutamyl transpeptidase; CRP: C-reactive protein; WBC: white blood cell count; HDL-Cholesterol: high density lipoprotein cholesterol; LDL-Cholesterol: low density lipoprotein; PSA: prostate-specific antigen; HR: heart rate.

Data availability statement

The data that support the findings of this study are available from the corresponding author, BYW, upon reasonable request.