Genetic evidence supporting a causal role of Janus kinase 2 in prostate cancer: a Mendelian randomization study

Figures & data

Figure 1. Experimental procedure of Mendelian randomization method applied to the causal relationship between JAK2 and prostate cancer.

The eight rectangular boxes from top to bottom contain the steps of research and design.

Figure 2. Forest plot of MR analysis of plasma protein JAK2 with PCa by IVW, weighted median, and MR Egger methods.

The horizontal line and midpoint of the three results showed the confidence intervals and median of the three results.

Figure 3. Scatter plot of MR analysis of plasma protein JAK2 with PCa by inverse variance weighted, weighted median, and MR Egger methods.

The scattered points and three implementations meant the correlation results obtained by the three methods.

Figure 4. Funnel plot of inverse variance weighted, MR Egger’s multiple validity test for worker IVs, with the vertical line in the middle indicating the sum of different effect sizes.

The shape formed by scattered points was similar to an inverted funnel.

Figure 5. Effect of leave-one-out plot responses on the overall estimation of the causal effect of JAK2 on PCa by removing IVs one by one.

Each line corresponds to the confidence interval of the MR analysis results when the SNP is removed.

Data availability statement

All data can be found in the IEU OpenGWAS Project database (https://gwas.mrcieu.ac.uk/).