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Musculoskeletal

Cost-effectiveness analysis of upadacitinib as a treatment option for patients with rheumatoid arthritis in the Kingdom of Saudi Arabia

, , , , , , , ORCID Icon, , , & show all
Pages 134-144 | Received 18 Sep 2023, Accepted 21 Dec 2023, Published online: 01 Jan 2024

Figures & data

Figure 1. Model structure.

Abbreviations: 1L: First-line; 2L: Second-line; 3L: Third-line; DAS28: Disease Activity Score 28; Tx: Treatment

Figure 1. Model structure.Abbreviations: 1L: First-line; 2L: Second-line; 3L: Third-line; DAS28: Disease Activity Score 28; Tx: Treatment

Figure 2. Treatment algorithm.

Abbreviations: DMARD: Disease modifying anti-rheumatic drug

Figure 2. Treatment algorithm.Abbreviations: DMARD: Disease modifying anti-rheumatic drug

Table 6. Cost breakdown and health outcomes with Upadacitinib - Scenario 2 (severe RA).

Figure 3. Total societal cost and QALY with upadacitinib – Scenario 1.

Abbreviations: RA: Rheumatoid Arthritis; SAR: Saudi Riyal; QALY: Quality-adjusted Life-year

Figure 3. Total societal cost and QALY with upadacitinib – Scenario 1.Abbreviations: RA: Rheumatoid Arthritis; SAR: Saudi Riyal; QALY: Quality-adjusted Life-year

Table 1. Health outcomes with Upadacitinib - Scenario 1.

Table 2. Cost breakdown and health outcomes with Upadacitinib - Scenario 1 (moderate RA).

Table 3. Cost breakdown and health outcomes with Upadacitinib - Scenario 1 (severe RA).

Figure 4. Total societal cost and QALY with upadacitinib – Scenario 2.

Abbreviations: RA: Rheumatoid Arthritis; SAR: Saudi Riyal; QALY: Quality-adjusted Life-year

Figure 4. Total societal cost and QALY with upadacitinib – Scenario 2.Abbreviations: RA: Rheumatoid Arthritis; SAR: Saudi Riyal; QALY: Quality-adjusted Life-year

Table 4. Health outcomes with Upadacitinib - Scenario 2.

Table 5. Cost breakdown and health outcomes with Upadacitinib - Scenario 2 (moderate RA).

Supplemental material

Supplemental Material

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Data availability statement

The data that support the findings of this study are available from the corresponding author, MA, upon reasonable request.