Clinical and economic outcomes of assigning percutaneous coronary intervention patients to contrast-sparing strategies based on the predicted risk of contrast-induced acute kidney injury

Figures & data

Figure 1. Prediction model for contrast-induced acute kidney injury.

Figure 2. Performance of the prediction model.

Figure 3. Projected impact of contrast sparing on (a) mortality and (b) MI readmission by CI-AKI risk threshold for assignment.

Figure 4. Projected impact of contrast sparing on (a) length of stay, (b) index admission cost and (c) cumulative one-year cost by CI-AKI risk threshold for assignment.

Table 1. Projected clinical and economic outcomes of contrast-sparing.

	Total events/cost per 100,000 PCI patients
Decision threshold	Percentage of PCI patients enrolled	Hospital days	Hospital cost	Total cost	MI readmissions	Deaths	NNT/death prevented
1.0 = None enrolled	0.0	592,367	$2,649,696,512	$5,297,766,912	12,392	15,430	See below
>0.20	0.0	592,352	$2,649,632,256	$5,297,227,776	12,392	15,430
>0.10	0.2	592,066	$2,648,537,600	$5,294,732,800	12,386	15,419
>0.09	0.3	591,928	$2,648,313,344	$5,293,931,520	12,385	15,419
>0.08	0.5	591,777	$2,648,034,560	$5,295,057,408	12,390	15,421
>0.07	1.0	591,402	$2,646,946,816	$5,291,773,440	12,381	15,408
>0.06	1.7	590,663	$2,644,567,040	$5,286,067,200	12,369	15,382
>0.05	3.2	590,165	$2,644,060,672	$5,285,454,848	12,365	15,374
>0.04	5.8	589,478	$2,641,480,448	$5,278,161,408	12,348	15,339
>0.03	10.6	588,064	$2,639,673,344	$5,274,427,392	12,340	15,321
>0.02	18.0	587,146	$2,638,370,048	$5,271,956,480	12,333	15,309
>0.01	28.9	586,209	$2,635,952,384	$5,266,630,144	12,322	15,285
0.0 = All enrolled	100.0	586,209	$2,633,163,264	$5,260,463,104	12,309	15,262
	Difference from none enrolled/100,000 PCI patients
1.0 = None enrolled	Reference case
>0.20	0.0	−15	−$64,256	−$539,136	0	0	0
>0.10	0.2	−301	−$1,158,912	−$3,034,112	−6	−11	18
>0.09	0.3	−439	−$1,383,168	−$3,835,392	−6	−11	29
>0.08	0.5	−590	−$1,661,952	−$2,709,504	−2	−9	56
>0.07	1.0	−965	−$2,749,696	−$5,993,472	−10	−22	46
>0.06	1.7	−1,704	−$5,129,472	−$11,699,712	−23	−48	36
>0.05	3.2	−2,202	−$5,638,840	−$12,312,064	−26	−56	57
>0.04	5.8	−3,193	−$8,216,064	−$19,605,504	−44	−90	64
>0.03	10.6	−3,889	−$10,023,168	−$23,339,520	−52	−109	98
>0.02	18.0	−4,303	−$11,326,464	−$25,810,432	−58	−121	149
>0.01	28.9	−5,220	−$13,744,128	−$31,136,768	−69	−145	200
0.0 = All Enrolled	100.0	−6,157	−$16,533,248	−$37,303,808	−83	−168	596