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Research Article

Antihyperglycaemic Effect of Scoparia dulcis.: Effect on Key Metabolic Enzymes of Carbohydrate Metabolism in Streptozotocin-Induced Diabetes

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Pages 570-576 | Accepted 14 Jul 2004, Published online: 07 Oct 2008

Figures & data

Table 1.. Effect of 3-week treatment with various doses of aqueous, ethanolic and chloroform extracts of Scoparia dulcis. on glucose in normal and experimental rats.

Figure 1. Body weight, fluid and food intake in streptozotocin diabetic rats before and after oral treatment with Scoparia dulcis. plant extract for 3 weeks. Groups: 1-Normal; 2-Diabetic control; 3-Diabetic + Aq-SPEt (200 mg/kg body weight); 4-Diabetic + Alc-SPEt (200 mg/kg body weight); 5-Diabetic + Chloro-SPEt (200 mg/kg body weight). Values are given as mean ± S.D from six rats in each group. Values not sharing a common superscript letter differ significantly at p < 0.05 (DMRT). Duncan Procedure; Ranges for the level: 2.95; 3.09; 3.20, 3.22 Diabetic control was compared with normal, p < 0.001. Experimental groups were compared with diabetic control p < 0.001.

Figure 1. Body weight, fluid and food intake in streptozotocin diabetic rats before and after oral treatment with Scoparia dulcis. plant extract for 3 weeks. Groups: 1-Normal; 2-Diabetic control; 3-Diabetic + Aq-SPEt (200 mg/kg body weight); 4-Diabetic + Alc-SPEt (200 mg/kg body weight); 5-Diabetic + Chloro-SPEt (200 mg/kg body weight). Values are given as mean ± S.D from six rats in each group. Values not sharing a common superscript letter differ significantly at p < 0.05 (DMRT). Duncan Procedure; Ranges for the level: 2.95; 3.09; 3.20, 3.22 Diabetic control was compared with normal, †p < 0.001. Experimental groups were compared with diabetic control ‡p < 0.001.

Table 2.. Changes in the levels of plasma insulin and tissue glycogen in normal and experimental animals.

Table 3.. Changes in the activities of hepatic hexokinase, glucose 6-phosphate dehydrogenase, glucose 6-phosphatase and fructose 1,6-bis phosphatase in normal and experimental rats.

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