Figures & data
Figure 1Inhibition of TPA-induced tumor promotion by multiple application of aqueous extract of Agaricus blazei. Murill (oral and topical administration). All mice were carcinogenically initiated with DMBA (390 nmol) and promoted with 1.7 nmol of TPA given twice weekly starting 1 week after initiation. (A) Percentage of mice bearing papillomas; (B) average number of papillomas per mouse. •, control TPA alone (group I); •, TPA + aqueous solution of the extract (one-time dose per mouse: 50 µg) of Agaricus blazei. Murill (group II); •, TPA + 0.0025% aqueous solution of the extract (average does of a mouse per day: 175–200 µg) (group III). At 20 weeks of promotion, groups II and III were different from group I (p < 0.05) regarding papillomas per mouse.
Figure 2Inhibition of UV-B–induced tumor promotion by multiple application of aqueous extract of Agaricus blazei. Murill (oral and topical administration). All mice were carcinogenically initiated with DMBA (390 nmol) and promoted with 8 min irradiation of UV-B (3430 J/m2) given twice weekly starting 1 week after initiation. (A) Percentage of mice bearing papillomas; (B) average number of papillomas per mouse. •, control UVB along (group IV); •, UV-B + aqueous solution of the extract (one-time dose per mouse: 50 µg) of Agaricus blazei. Murill (group V); ◯, UV-B + 0.0025% aqueous solution of the extract (average dose of a mouse per day: 175–200 µg) (group VI). At 20 weeks of promotion, groups V and VI were different from group IV (p < 0.05) regarding papillomas per mouse.
