Antiprotozoal Activity Against Plasmodium falciparum. and Trypanosoma cruzi. of Aeroplysinin-1 Isolated from the New Sponge Aplysina chiriquensis.

Marcelino Gutiérrez Departamento de Química Orgánica, Instituto de Acuicultura y Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, Santiago de Compostela, Spain

Todd L. Capson Smithsonian Tropical Research Institute, Balboa, Ancon, Republic of Panama

Héctor M. Guzmán Smithsonian Tropical Research Institute, Balboa, Ancon, Republic of Panama

José González Institute of Advanced Scientific Investigations and High Technology Services, Secretariat for Science and Technology, Clayton, Panama

Eduardo Ortega-Barría Institute of Advanced Scientific Investigations and High Technology Services, Secretariat for Science and Technology, Clayton, Panama

Emilio Quiñoá Departamento de Química Orgánica, Instituto de Acuicultura y Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, Santiago de Compostela, Spain

Ricardo Riguera Departamento de Química Orgánica, Instituto de Acuicultura y Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, Santiago de Compostela, Spain

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Figures & data

Figure 1 Structures of compounds 1–5 isolated from A. chiriquensis. and A. gerardogreeni..

Table 1.. Relative concentration (% by HPLC) of compounds 1–5 in the dichloromethane extracts of Aplysina. specimens C1, C3, C10, C11, and C31.

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Table 2.. Activity of compounds 1–5 against chloroquine-resistant Plasmodium falciparum. and intracellular Trypanosoma cruzi..

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Antiprotozoal Activity Against Plasmodium falciparum. and Trypanosoma cruzi. of Aeroplysinin-1 Isolated from the New Sponge Aplysina chiriquensis.

Table 1.. Relative concentration (% by HPLC) of compounds 1–5 in the dichloromethane extracts of Aplysina. specimens C1, C3, C10, C11, and C31.

Table 2.. Activity of compounds 1–5 against chloroquine-resistant Plasmodium falciparum. and intracellular Trypanosoma cruzi..

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Antiprotozoal Activity Against Plasmodium falciparum. and Trypanosoma cruzi. of Aeroplysinin-1 Isolated from the New Sponge Aplysina chiriquensis.

Figures & data

Table 1.. Relative concentration (% by HPLC) of compounds 1–5 in the dichloromethane extracts of Aplysina. specimens C1, C3, C10, C11, and C31.

Table 2.. Activity of compounds 1–5 against chloroquine-resistant Plasmodium falciparum. and intracellular Trypanosoma cruzi..

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