Gymnemic Acids from Gymnema sylvestre. Potentially Regulates Dexamethasone-Induced Hyperglycemia in Mice

Figures & data

Table 1.. Effect of different doses of gymnemic acid (GA) in serum concentrations of glucose (mg %), T₃ (ng/ml), T₄ (ng/ml), and hepatic LPO (nM MDA formed h⁻¹ mg protein⁻¹), SOD (units/mg protein) and CAT (μM of H₂O₂ decomposed min^-1 mg protein⁻¹) activities in normoglycemic and dexamethasone-induced hyperglycemic mice.

Groups	Glucose	T3	T4	LPO	SOD	CAT
I. Vehicle control	52.47 ± 1.19	0.75 ± 0.05	31.40 ± 1.84	0.79 ± 0.05	5.14 ± 0.24	65.38 ± 0.48
II. Dexamethasone (Dexa)	75.52 ± 2.54***	0.59 ± 0.04	24.06 ± 2.19	0.71 ± 0.04	6.56 ± 0.24***	72.71 ± 1.47***
III. Dexa + GA (6.7 mg/kg)	72.41 ± 2.43	0.63 ± 0.06	25.07 ± 1.75	0.64 ± 0.04	6.72 ± 0.25	71.49 ± 1.39
IV. Dexa + GA (13.4 mg/kg)	53.80 ± 2.44***	0.68 ± 0.06	26.70 ± 2.26	0.55 ± 0.04	7.79 ± 0.34	74.05 ± 1.42
V. Dexa + GA (26.8 mg/kg)	59.12 ± 3.62**	0.65 ± 0.05	28.20 ± 2.41	2.79 ± 0.48**	5.13 ± 0.18***	60.58 ± 2.35**
VI. Dexa + ketoconazole	68.67 ± 1.97	0.66 ± 0.07	25.17 ± 2.76	0.84 ± 0.05	6.11 ± 0.36	71.75 ± 2.12
VII. GA (6.7 mg/kg,)	55.32 ± 1.72	0.65 ± 0.05	26.13 ± 2.75	0.65 ± 0.03	6.05 ± 0.20	67.46 ± 0.98
VIII. GA (13.4 mg/kg)	44.43 ± 1.41†††	0.48 ± 0.04†††	23.31 ± 1.59††	0.77 ± 0.03	6.82 ± 0.23†††	69.21 ± 1.11††
IX. GA (26.8 mg/kg)	45.73 ± 1.29†††	0.49 ± 0.05†††	24.12 ± 1.71	1.20 ± 0.24	4.73 ± 0.22	55.77 ± 2.62†††
X. Ketoconazole	42.50 ± 2.75††	0.61 ± 0.05	28.23 ± 2.17	0.76 ± 0.05	5.25 ± 0.35	66.94 ± 2.34

LPO, lipid peroxidase; SOD, superoxide dismutase; CAT, catalase.

Data are mean ± SEM (n. = 8). †p. < 0.05; ††p. < 0.01 and †††p. < 0.001 as compared to the respective control values.

*p. < 0.05, **p. < 0.01, ***p. < 0.001 as compared to the respective values of the dexamethasone-treated groups.