Antidiabetic Activity of Some Indian Medicinal Plants

Figures & data

Table 1 Effect of aqueous extract of drugs on the blood glucose level of normal fasted rats.

		Blood glucose level mg/100 ml
Groups	Treatment	Initial	2 h	4 h
I	Control	86.16 ± 3.10	83.83 ± 3.54	84.11 ± 3.42
II	Glibenclamide (3 mg/kg)	84.83 ± 2.85	46.83 ± 4.57^a.	48.5 ± 4.64^a.
III	Syzygium cumini. (200 mg/kg)	84.66 ± 3.15	54.12 ± 4.02^a.	55.63 ± 3.72^a.
IV	Gymnema slyvestre. (200 mg/kg)	79.33 ± 2.81	58.33 ± 4.86^a.	63.16 ± 3.75^a.
V	Portulaca olearacea. (200 mg/kg)	79.66 ± 3.04	82.31 ± 3.05	84.16 ± 3.54

All values are mean±SEM.

^a.p < 0.01 when compared with control.

Table 2 Effect of aqueous extract of drugs on the oral glucose tolerance test of normal fasted rats.

		Blood glucose level mg/100 ml
Groups	Treatment	Initial	30 m	90 m	180 m
I	Control	82.18 ± 2.32	128.43 ± 3.35	120.61 ± 3.67	111.23 ± 3.94
II	Glibenclamide (3 mg/kg)	84.32 ± 2.12	108.15 ± 3.36	96.34 ± 2.62^a.	89.45 ± 2.81^a.
III	Syzygium cumini. (200 mg/kg)	86.83 ± 1.86	110.5 ± 2.33	100.83 ± 2.15^a.	91.33 ± 3.46^a.
IV	Gymnema slyvestre. (200 mg/kg)	82.16 ± 1.42	108.16 ± 3.19	98.52 ± 2.81^a.	88.34 ± 2.3^a.
V	Portulaca olearacea. (200 mg/kg)	82.5 ± 2.36	123.4 ± 4.33	112.33 ± 3.98	102.33 ± 3.71

All values are mean±SEM.

^a.p < 0.01 when compared with control.

Table 3 Effect of aqueous extract of drugs on the glucose level of diabetic rats.

		Blood glucose level mg/100 ml
Groups	Treatment	Initial	2 h	4 h
I	Control (normal)	82.24 ± 3.64	81.63 ± 2.84	82.47 ± 2.35
II	Diabetic control	281.56 ± 8.25^a.	276.36 ± 7.58^a.	280.12 ± 8.64^a.
III	Glibenclamide (3 mg/kg)	283.85 ± 8.75	244.38 ± 10.21^c.	218.15 ± 12.64^b.
IV	Syzygium cumini. (200 mg/kg)	282.42 ± 9.12	251.37 ± 11.68	238.29 ± 13.67^c.
V	Gymnema slyvestre. (200 mg/kg)	288.44 ± 10.12	255.71 ± 13.45	234.86 ± 13.25^c.
VI	Portulaca olearaceae. (200 mg/kg)	285.54 ± 8.64	282.26 ± 9.52	286.73 ± 9.24

All values are mean±SEM.

^a.p < 0.001 when compared with normal control (group I).

^b.p < 0.01 when compared with diabetic control (group II).

^c.p < 0.05 when compared with diabetic control (group II).