Anti-inflammatory and Antipyretic Activity of Decalepis hamiltonii. Root Extract

Figures & data

Table 1 Effect of Decalepis hamiltonii extract on inflammatory models.

Treatment	Dose (mg/kg)	% Inhibition of paw edema inflammation at 3 h	Weight of granuloma (mg/100 g)
Control	0.00	0.00	63.8 ± 1.89
Methanol extract	250	62.63	42.6 ± 2.31
Methanol extract	500	83.19	37.2 ± 3.13
Diclofenac sodium	13.5	89.26	30.5 ± 1.90

Values are mean ± SE, n = 6, *p < 0.05 significant.

Table 2 Effect of Decalepis hamiltonii extract on yeast-induced pyrexia.

		Rectal temperature (°C) before and after treatment
Treatment	Dose (mg/kg)	0 h	18 h	1 h	2 h	3 h	4 h
Control	0.00	37.6 ± 0.2	39.3 ± 0.1	39.1 ± 0.1	39.1 ± 0.2	39.1 ± 0.02	39.1 ± 0.01
Methanol extract	250	37.6 ± 0.2	39.6 ± 0.1	38.1 ± 0.2	38.1 ± 0.1	38.0 ± 0.1	37.9 ± 0.3
	500	37.7 ± 0.1	39.6 ± 0.1	38.0 ± 0.1	38.0 ± 0.1	37.9 ± 0.1	37.8 ± 0.2
Paracetamol	100	37.8 ± 0.2	39.5 ± 0.1	38.2 ± 0.3	38.2 ± 0.2	38.0 ± 0.4	37.8 ± 0.3

Values are mean ± SEM, n = 6, *p < 0.05.